Letter | Published:

Light-scattering Studies on Penicillin G Solutions

Naturevolume 168pages423424 (1951) | Download Citation



LITERATURE concerning the physical-chemical state of aqueous systems of penicillin reveals a controversial issue. Claims that micelles, between 200 A. and 5000 A. in length, are formed above a critical concentration of 10,000 units/c.c. (0.6 per cent)1–4 contrast with evidence which indicates that penicillins behave as simple electrolytes5–9. One paper5 reports that colloidal electrolyte behaviour is not reached until 8.26 per cent, a concentration so high as to be of little biological importance.

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  1. 1

    Hauser, E. A., Kolloid Z., 111, 103 (1948).

  2. 2

    Hauser, E. A., and Marlowe, G. J., J. Phys. Coll. Chem., 54, 1077 (1950).

  3. 3

    Hauser, E. A., Phillips, R. G., and Phillips, J. W., Science, 106, 616 (1947).

  4. 4

    Hauser, E. A., Phillips, R. G., Phillips, J. W., and Vavruch, I., J. Phys. Coll. Chem., 53, 287 (1949).

  5. 5

    McBain, J. W., Huff, H., and Brady, A. P., J. Amer. Chem. Soc., 71, 373 (1949).

  6. 6

    Kumer, W. D., and Alpen, E. L., Science, 107, 567 (1948).

  7. 7

    Lund, C. G., and Pedersen-Bjergaard, K., Science, 109, 149 (1949).

  8. 8

    Klenow, H., Acta Chem. Scandinavia, 1, 328 (1947).

  9. 9

    Woodbury, D. T., and Rosenblum, C., J. Biol. Chem., 171, 447 (1947).

  10. 10

    Debye, P., J. Phys. Coll. Chem., 53, 1 (1949).

  11. 11

    Oster, G., Chem. Rev., 43, 319 (1948).

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  1. C. S. HOCKING: Rotary Foundation Fellow, Adelaide, Australia.


  1. Baker Laboratory of Chemistry, Cornell University, Ithaca, New York

    • C. S. HOCKING


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