Abstract
RECENT experiments indicate that a relationship might exist between aminopterin and adrenal cortex function. Dougherty and Dougherty1 report that, following adrenalectomy, mice do not show the lymphopænia and acute atrophy of lymphatic tissue which are observed following a lethal dose of aminopterin. Higgins2, using aminopterin and aminoteropterin, showed that adrenalectomy minimized considerably the changes induced by such drugs within the spleen, the thymus gland, the peripheral blood and bone marrow of rats. They assumed that some effects of aminopterin can be due to a stimulation of the adrenal cortex. On the other hand, Hanlon3 of the Mayo Clinic has observed that aminopterin in human subjects gives a rather marked decrease in the output of corticosteroids and, in no case, an increase.
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References
Dougherty, J. H., and Dougherty, T. F., J. Lab. Clin. Med., 35, 271 (1950).
Higgins, G. M., Proc. Staff Meet. Mayo Clinic, 24, 533 (1949).
Hanlon, D. G., Mason, H. L., and Stickney, J. M., J. Lab. and Clin. Med., 36, 877 (1950).
Pilot, M. L., Amer. J. Clin. Path., 20, 870 (1950).
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TRAINA, V. Adrenotropic Hormone (ACTH), Aminopterin and Eosinophil Count. Nature 168, 250 (1951). https://doi.org/10.1038/168250a0
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DOI: https://doi.org/10.1038/168250a0
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