Abstract
IN the course of work on the purification of staphylocoagulase, a possible approach appeared to be the production of the enzyme in a protein-free ‘synthetic’ medium. While growth of Staphylococcus aureus occurs according to Fildes et al.1, Gladstone2 and Gale3 in media simpler than that reported here, for our purpose, which is concerned exclusively with the production of coagulase, a medium containing a wide range of amino-acids and vitamins seemed advisable. This medium has yielded good growth of a number of freshly isolated strains of coagulase-positive staphylococci, without prior ‘training’.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fildes, P., Richardson, G. M., Knight, B. C. J. G., and Gladstone, G. P., Brit. J. Exp. Path., 17, 481 (1936).
Gladstone, G. P., Brit. J. Exp. Path., 18, 322 (1937).
Gale, E. F., Symposium of the Soc. for Exp. Biol., No. 3, 233 (Camb. Univ. Press, 1949).
Tager, M., Yale J. Biol. Med., 20, 487 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LOMINSKI, I., O'HEA, A., GOUDIE, J. et al. Production of Staphylocoagulase in a Chemically Defined Medium. Nature 166, 309–310 (1950). https://doi.org/10.1038/166309b0
Issue Date:
DOI: https://doi.org/10.1038/166309b0
This article is cited by
-
Beobachtungen über die gegenseitige Beeinflussung von Zellen eines Makroorganismus und pathogenen Mikroorganismen an einem Infektionsmodell
Zeitschrift für Hygiene und Infektionskrankheiten (1960)
-
über die Beeinflussung der Coagulasebildung durch Nucleinsäuren
Zeitschrift für Hygiene und Infektionskrankheiten (1958)
-
Untersuchungen über den Coagulasestoffwechsel der pathogenen Staphylokokken
Zeitschrift für Hygiene und Infektionskrankheiten (1957)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
