Letter | Published:

Reciprocal Detoxifying Effects of ‘Benadryl’ and ‘Aminopterin’

Naturevolume 166page158 (1950) | Download Citation



AN attempt has been made to overcome the toxic effect of the 4-aminopteroylglutamic acid, the new powerful folic acid antagonist1. Aminopterin is toxic to all laboratory animals used and also to human beings2–7. Its toxic effects are difficult to prevent or to reverse by administration of folic acid6–10, whereas the effects of theX-methyl analogues of folic acid are easily reversed by administration, of folic acid6. In the experiments reported here, ‘Benadryl’ was used in an attempt to antagonize the toxic effects of ‘Aminopterin’.

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  1. Department of Pathology, Fairview Park Hospital, Cleveland, Ohio

    • V. TRAINA


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