Distribution of Protein in the Tissues of Rats Treated with Anterior-Pituitary Growth-Hormone


RATS treated with growth-promoting anterior-pituitary extracts1 or with purified pituitary growth-hormone2 gain more body-weight than pair-fed control animals. In experiments with rats, cats and dogs fed a constant amount of food throughout the experiment, Young3 found that diabetogenic growth-promoting anterior-pituitary extract induced a substantial rise in body-weight even when, as with the dog and the cat, a severely diabetic condition simultaneously developed. In all these investigations evidence was adduced to show that the rise in body-weight in the pituitary-treated animals resulted mainly from a deposition of protein-containing tissue. The present experiments were designed to indicate the site of the protein deposited in the bodies of pair-fed rats treated with purified pituitary growth-hormone.

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  1. 1

    Lee, M. O., and Schaffer, N. K., J. Nutrit., 7, 337 (1934).

  2. 2

    Evans, H. M., Simpson, M. E., and Li, C. H., Growth, 12, 15 (1948).

  3. 3

    Young, F. G., Biochem. J., 39, 515 (1945).

  4. 4

    Wilhelmi, A. E., Fishman, J. B., and Russell, J. A., J. Biol. Chem., 176, 735 (1948).

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GREENBAUM, A., YOUNG, F. Distribution of Protein in the Tissues of Rats Treated with Anterior-Pituitary Growth-Hormone. Nature 165, 521–522 (1950) doi:10.1038/165521b0

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