Letter | Published:

Antibacterial Action of Curcumin and Related Compounds



INVESTIGATIONS by A. R. Todd1, H. Rinderknecht2, W. B. Geiger3 and others have shown that many unsaturated ketones with the grouping —C = C—CO—, also present in a number of naturally occurring antibiotics, possess antibacterial action. In our studies on unsaturated ketones, we found that chalkone, flavanone, flavone and some of their derivatives, for example, buteine (2,4,3',4'-tetrahydroxychalkone). a substance of vegetable origin, showed a marked inhibition of the growth of Staph. aureus. Also extracts of plants containing flavanones, flavones or flavonoles were found to be bacteriostatic4. Furthermore, we have prepared a number of synthetic chalkones of which some compounds suppressed the growth at high dilutions.

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  1. 1

    Marrian, D. H., Russell, P. B., and Todd, A. R., J. Chem. Soc., 1419 (1947).

  2. 2

    Rinderknecht, H., Ward, J. L., Bergel, F., and Morrison, A. L., Biochem. J., 41, 463 (1947).

  3. 3

    Geiger, W. B., Arch. Biochem., 16, 423 (1948).

  4. 4

    Schraufstätter, E., Experientia, 4, 484 (1948).

  5. 5

    Schraufstätter, E., and Deutsch, S., Z. Naturforsch., 3 b, 163 (1948).

  6. 6

    Schraufstätter, E., Richter, R., and Ditseheid, W., Arch. f. Dermatol. u. Syph., 188, 259 (1949).

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