Abstract
THE production of ‘biochemical ‘mutants of fungi by means of ultra-violet or X-radiation has been reported by Beadle and Tatum1,2 (Neurospora spp.), Fries3,4,5,6 (Ophiostoma spp.) and Pontecorvo7 (Aspergillus and Penicillium spp.). Following the use of mustard-gas (β,β'-dichlorodiethyl sulphide) in producing mutations in the vinegar fly (Drosophila melanogaster) by Auerbach and Robson8, this reagent has been used by Horowitz et al.9 to produce mutations in Neurospora spp. A method for isolating strains of Aspergillus nidulans deficient for a specific amino-acid, cystine, from a mixture of mutants produced by mustard-gas, is now described. These special mutants grow normally in presence of cystine but are unable to grow with sulphate as sole sulphur source.
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Horowitz, N. H., Houlahan, M. B., Hungate, M. G., and Wright, B., Science, 104, 233 (1946).
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HOCKENHULL, D. Mustard-gas Mutation in Aspergillus nidulans. Nature 161, 100 (1948). https://doi.org/10.1038/161100a0
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DOI: https://doi.org/10.1038/161100a0
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