Letter | Published:

Benziminazoles Related to Paludrine

Nature volume 160, page 53 (12 July 1947) | Download Citation



The suggestion recently made in these columns by Hawking1, that the drug paludrine is not itself an antimalarial agent but is converted into an active compound in vivo, opens up a wide field for speculation and research. No indication has yet been obtained as to the nature of this transformation product; but one of the more obvious hypotheses as to the fate of paludrine in the body appears to be excluded by an investigation which we have lately completed.

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    , Nature, 159, 409 (1947).

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    , J. Biol. Chem., 152, 225 (1944).

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    and , Nature, 158, 707 (1946).

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    , Gazz. Chim. Ital., 51, 140 (1921).

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    , J. Amer. Chem. Soc., 64, 187 (1942).

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  1. Dyson Perrins Laboratory, Oxford. April 19.

    • R. M. ACHESON
    • , F. E. KING
    •  & P. C. SPENSLEY


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