Letter | Published:

Cis-Trans Isomerism of Diethylstilbstrol

Nature volume 158, page 790 (30 November 1946) | Download Citation



Walton and Brownlee1 have reported the conversion of pure ψ-diethylstilbœstrol (cis ?) into diethylstilbœstrol (trans) in 80 per cent yield by heating with alcoholic hydrochloric acid. Recent work in this laboratory has shown that heating with 2.5 N aqueous hydrochloric acid for periods of 30 min.—2 hr. converts both ψ-diethylstilbœstrol and diethylstilbœstrol into an equilibrium mixture in which, in so far as these two substances are concerned, diethylstilbœstrol preponderates in the ratio 9 : 1. The change has been followed by melting-point and colorimetric estimations2 of the products isolated from saturated acid solutions after cooling to room temperature, and checked by comparison with the properties of suitable mechanical mixtures.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    , and , Nature, 151, 305 (1943).

  2. 2.

    , Biochem. J., 39, 95 (1945).

Download references

Author information


  1. National Institute for Research in Dairying, Shinfield, Nr. Reading. Oct. 21.

    • F. H. MALPRESS


  1. Search for F. H. MALPRESS in:

About this article

Publication history





By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.