Antimalarial Action of Cinnoline Derivatives


A NOTEWORTHY feature of the published synthetic work relevant to the chemotherapy of malaria is the extent to which attention has been concentrated on the preparation of active agents derived from either quinoline or acridine, of which the two outstanding examples are respectively, pamaquin and mepacrine. By comparison, little information is available concerning the effectiveness of other structural types, with the important exception of paludrine, the discovery of which was announced recently1.

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    Nature, 156, 596 (1945).

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    J. Gen. Chem. U.S.S.R., 8, 1797 (1938). Chem. Abs., 33, 4993 (1939).

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    Schönhofer, Z. physiol. Chem., 274, 1 (1942).

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    Eng. Pat. Appl. 27673/38.

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    Ann. Trap. Med. and Parisitol., 39, 139 (1945).

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SIMPSON, J., SCHOFIELD, K. Antimalarial Action of Cinnoline Derivatives. Nature 157, 439–440 (1946) doi:10.1038/157439c0

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