Activity of Helvolic Acid against Mycobacterium tuberculosis


THE earliest account of an action by Aspergillus fumigatus on the tubercle bacillus appears to be that of Vaudremer, who found that Myco, tuberculosis incubated for 24 days in a filtered extract of A. fumigatus lost to a large extent its acid-fast staining properties and its virulence for animals, as compared with bacilli incubated in Raulin's culture fluid or in saline1. The active principle was thermostable2. He used similar extracts to treat more than two hundred patients with tuberculosis, but clinical results were equivocal3. He also pursued the idea of using the attenuated bacilli for the preparation of vaccines4,5.


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JENNINGS, M. Activity of Helvolic Acid against Mycobacterium tuberculosis. Nature 156, 633 (1945).

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