Abstract
IN tests conducted in these laboratories, p-amino-benzoic acid and the n-butyl p-aminobenzoate have shown definite reduction in rate of growth of three representative moulds (species of Aspergillus, Penicillium and Byssochlamys) growing on Czapek-Dox agar medium, pH 4. Inhibition in the case of the free acid was very marked (at least 50 per cent) at a concentration of 5·6 millimolar (mm.) and a reduction could still be detected, in the case of Aspergillus, as low as 0·18 mm. The butyl ester proved more effective, greater than 70 per cent reduction being observed at 1·0 mm. and a marked effect persisting as low as 0·14 mm.—the lowest concentration tested. In cases of the intermediate and lower concentrations of the free acid, the colonies remained regular in outline and maintained a steady though reduced rate of increase; concentrations 9·8 and 5·6 mm. gave rise to very irregular and fluctuating growth. With the higher concentrations of both substances, particularly of the p-aminobenzoic acid, an orange-yellow pigmentation was observed both in the mycelial felt and in the surrounding medium1, 2.
References
Mayer, R. L., Science, 98, 203 (1943).
Mayer, R. L., J. Bact., 48, 93 (1944).
Woods, D. D., Brit. J. Exp. Path., 21, 74 (1940).
Tamura, J. T., J. Bact., 47, 529 (1944).
Johnson, F. H., Carver, C. M., Harryman, W. K., J. Bact., 44, 703 (1942).
Lee, S. W., and Foley, E. J., Proc. Soc. Exp. Biol. Med., 53, 243 (1943).
Lavor, E. M., and Ferguson, F. F., J. Elisha Mitchell Sci. Soc., 58, 166 (1942); C.A., 37, 2083 (1943).
Kuhn, R., and Schwarz, K., Ber., 74B, 1617 (1941); Chem. Abs., 37, 357 (1943).
Kuhn, R., Moller, E. F., Wendt, G., and Beirnert, H., Ber., 75B, 711 (1942); Chem. Abs., 36, 7017 (1942).
Rubbo, S. D., and Gillespie, J. M., Nature, 146, 838 (1940).
Landy, M., and Dicken, D. M., J. Biol. Chem., 146, 109 (1942).
Goetchius, G. R., and Lawrence, C. A., J. Bact., 47, 450 (1944).
Hirsch, J., Science, 96, 139 (1942).
Auhagen, E., Z. physiol. Chem., 274, 48 (1942); Chem. Abs., 37, 5100 (1943).
Wyss, O., Rubin, M., and Strandskov, F. B., Proc. Soc. Exp. Biol. Med., 52, 155 (1943).
Johnson, O. H., Green, D. E., and Pauli, R., J. Biol. Chem., 153, 37 (1944).
Lamanna, C., and Shapiro, I. M., J. Bact., 45, 385 (1943).
Lewis, J. C., J. Biol. Chem., 146, 441 (1942).
Thompson, R. C., Isbell, E. R., and Mitchell, H. K., J. Biol. Chem., 148, 281 (1943).
Blanchard, K. C., J. Biol. Chem., 140, 919 (1941).
Green, D. E., and Stumpf, P. K., Ann. Rev. Biochem., 13, 1 (1944).
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CAVILL, G., VINCENT, J. Inhibition of Mould Growth by p-Aminobenzoic Acid and the n-Butyl Ester. Nature 155, 301 (1945). https://doi.org/10.1038/155301a0
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DOI: https://doi.org/10.1038/155301a0
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