Letter | Published:

Fetuin, a New Globulin Isolated from Serum

Nature volume 154, page 575 (04 November 1944) | Download Citation



DURING a study on the fractionation of serum with ammonium sulphate, I thought it worth while to try whether some of the serum proteins could be isolated more easily from the serum of a newly born animal. Serum from calves not more than two weeks old was used for these fractionation experiments, which immediately indicated a pronounced difference between the serum from the calf and that from the cow. Ultracentrifugal examination of the different fractions revealed the presence of large amounts of a globulin with the sedimentation constant, 820, of the order 3S (LS (Svedberg) = 1 × 10–13 C.G.S.) as compared with the normal 820 ˜7S for serum globulin. The main part of the new protein was precipitated between the salt concentration limits 0·37 and 0·45 saturated ammonium sulphate. It was purified further by fractionation with ammonium sulphate and centrifugation in a high-speed air-driven centrifuge. Molecular weight determination gave a value of the order 50,0001.

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  1. Institute of Physical Chemistry, University, Uppsala. Sept. 13.



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