Mechanism of Enzymic Decarboxylation


A THEORY of the mechanism of the enzymic decarboxylation of pyruvic acid is suggested, which, though not yet capable of strict experimental proof, is consistent with many recent observations.

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  1. 1

    Langenbeck, W., Ergebn. Enzymforschung, 2, 314 (1933).

    CAS  Google Scholar 

  2. 2

    Braunstein, A. E., and Kritzmann, M. G., Enzymologia, 2, 129 (1937).

    Google Scholar 

  3. 3

    Knoop, F., Z. physiol. Chem., 67, 481 (1910).

    Article  Google Scholar 

  4. 4

    Knoop, F., and Kertess, E., Z. physiol. Chem., 71, 252 (1911).

    CAS  Article  Google Scholar 

  5. 5

    du Vigneaud, V., and Irish, O., J. Biol. Chem., 122, 349 (1937).

    Google Scholar 

  6. 6

    du Vigneaud, V., Cohn, M., Brown, G. B., Irish, O., Schoenheimer, R., and Rittenberg, D., J. Biol. Chem., 131, 273 (1939).

    CAS  Google Scholar 

  7. 7

    Lipmann, F., and Perlmann, G., J. Amer. Chem. Soc., 60, 2574 (1938).

    CAS  Article  Google Scholar 

  8. 8

    Lipmann, F., NATURE, 143, 436 (1939).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Weil-Malherbe, H., Biochem. J., 31, 2202 (1937).

    CAS  Article  Google Scholar 

  10. 10

    Quastel, J. H., and Webley, D. M., NATURE, 144, 633 (1939).

    ADS  CAS  Article  Google Scholar 

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WEIL-MALHERBE, H. Mechanism of Enzymic Decarboxylation. Nature 145, 106–107 (1940).

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