Abstract
IN NATURE of October 8, 1938, Duszynska gave an account of seasonal variation in the response of ovariectomized mice to œstrone, and described an annual cycle of sensitivity which was greatest in spring and lowest in autumn. In the accompanying figure, I have plotted the variations in the dose of international standard œstrone needed to give 50 per cent positive responses when given by injection to groups of ovariectomized mice belonging to colonies kept at this Institute during the past twenty months.
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References
Emmens, Med. Res. Coun. Sp. Sep. Ser., No. 234. In the Press. H. M. Stationery Office, London, 1939.
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EMMENS, C. Time-to-Time Variation in the Response of Ovariectomized Mice to œstrone. Nature 143, 476–477 (1939). https://doi.org/10.1038/143476a0
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DOI: https://doi.org/10.1038/143476a0
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