Use of Amino-Acids containing Deuterium to follow Protein Production in the Organism

Abstract

WHEN α-amino-acids are heated to 100–170° with heavy water and strong acids or bases, heavy hydrogen (D) is introduced in a stable or practically stable position in the amino-acid molecule1,2. The position into which D is introduced seems to be the C—H linkage at the α-C atom ; and further into the ring of some of the aromatic and the heterocyclio amino-acids.

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References

  1. 1

    Gü nther, G., Diss. Leipzig (1937).

  2. 2

    Krogh, A., and Ussing, H. H., C. R. Lab. Carlsberg, Ser. chim., 22, 282–287 (1938).

  3. 3

    Addis, T., Poo, L., and Lew, W., J. Biol. Chem., 115, 11, 117 (1936).

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USSING, H. Use of Amino-Acids containing Deuterium to follow Protein Production in the Organism. Nature 142, 399–400 (1938). https://doi.org/10.1038/142399b0

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