Abstract
Transforming growth factor betas (TGFβs) are potent immunosuppressive molecules released in the brain after injury. We hypothesized that TGFβ levels in cerebrospinal fluid (CSF) of schizophrenic patients would be altered because TGFβ can influence neural cell adhesion moelecule (N-CAM) expression in vitro. The levels of TGFβ1 and β2 in CSF of patients with schizophrenia and normal controls measured by ELISA showed no differences. There was evidence that the stability of TGFβ in CSF may be altered in schizophrenia. For a limited sample, TGFβ1 and N-CAM concentrations were significantly correlated in normal patients (r = 0.98) but not in schizophrenics. The results do not support an active neurodegeneration or anti-inflammatory response in the central nervous system, which is reflected in the CSF of chronic schizophrenics.
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Vawter, M., Dillon-Carter, O., Issa, F. et al. Transforming Growth Factors β1 and β2 in the Cerebrospinal Fluid of Chronic Schizophrenic Patients. Neuropsychopharmacol 16, 83–87 (1997). https://doi.org/10.1016/S0893-133X(96)00143-1
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DOI: https://doi.org/10.1016/S0893-133X(96)00143-1
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