Abstract
CORRELATION of molecular structure of the sex hormones with that of the sterols and bile acids is now almost complete, and leads to the conclusion that the hormones are biological degradation products of cholesterol. Adopting the working hypothesis that the male hormone (androsterone) is the immediate precursor of the female hormone (“strone), a study of the action of various tissue extracts on androsterone has been commenced in the hope of converting this hormone into “strone by biochemical means. The “strus test gives a very sensitive method of detecting any such conversion.
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References
Brouha and Simonnet, C.R. Soc. Biol., 99, 41; 1928.
St. Skowron and E. Turyna, Pol. Gaz. Lek., Nr. 18; 1934. St. Skowron, NATURE, 134, 627; 1934.
Ruzicka, Goldberg, Meyer, Brüngger and Eichenberger, Helv. Chim. Acta, 17, 1395; 1934.
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WARREN, F. Alleged strogenic Activity of the Male Sex Hormone. Nature 135, 234 (1935). https://doi.org/10.1038/135234b0
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DOI: https://doi.org/10.1038/135234b0
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