Letter | Published:

Coagulation of the Blood as a Chain-Reaction

Naturevolume 135page1075 (1935) | Download Citation



IN studies on the mechanism of the coagulation of blood, I have found that an active principle of coagulation is formed in the process of coagulation—a principle which can be transferred indefinitely into new plasma without decrease in its activity. In one experiment, 30 of an active phosphatide1 was added to a certain amount of chick plasma. About one minute before coagulation took place, another similar portion of plasma was inoculated with 0.03 c.c. of the first plasma, which was still liquid. Before coagulation of the second plasma took place a third portion of plasma was inoculated ; then the coagulation time of the second plasma was recorded. Then a fourth portion of plasma was inoculated from the third, and the coagulation time of the third plasma was recorded. Inoculation of a series of plasmas was continued in this way successively until the original amount of active phosphatide added was diluted to 5 × 1010, and the experiment was discontinued. The clotting time was practically constant through all the passages.

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  1. 1

    Fischer, A., and Hecht, E., Biochem. Z., 269, 115 ; 1934.

  2. 2

    Christiansen, J. A., and Kramers, Z. phys. Chem., 104, 451 ; 1923.

  3. 3

    Hinshelwood, C. N., and Grant, G. H., Proc. Roy. Soc., A, 141, 29 ; 1933.

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  1. Carlsberg Foundation, Copenhagen



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