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Mechanisms of cell transformation by papillomavirus E5 proteins

Oncogene volume 20, pages 7866–7873 (2001)Cite this article

Abstract

The papillomavirus E5 proteins are short, hydrophobic transforming proteins. The transmembrane E5 protein encoded by bovine papillomavirus transforms cells by activating the platelet-derived growth factor β receptor tyrosine kinase in a ligand-independent fashion. The bovine papillomavirus E5 protein forms a stable complex with the receptor, thereby inducing receptor dimerization and activation, trans-phosphorylation, and recruitment of cellular signaling proteins to the receptor. The E5 proteins of the human papillomaviruses also appear to affect the activity of growth factor receptors and their signaling pathways. The interaction of papillomavirus E5 proteins with a subunit of the vacuolar ATPase may also contribute to transformation. Further analysis of these unique mechanisms of viral transformation will yield new insight into the regulation of growth factor receptor activity and cellular signal transduction pathways.

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Acknowledgements

We thank Lisa Petti and Steven Smith and their colleagues for permission to cite unpublished work, Steven Smith and Omar Bakht for preparation of Figure 2, and Jan Zulkeski for typing this manuscript. The work in the authors' laboratory was supported by a grant from the National Institutes of Health (CA37157). D Mattoon is supported by a Bayer Predoctoral Fellowship.

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  1. Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, CT 06510, USA

    Daniel DiMaio & Dawn Mattoon

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Correspondence to Daniel DiMaio.

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DiMaio, D., Mattoon, D. Mechanisms of cell transformation by papillomavirus E5 proteins. Oncogene 20, 7866–7873 (2001). https://doi.org/10.1038/sj.onc.1204915

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