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Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

Oncogene volume 18, pages 6925–6937 (1999)Cite this article

Abstract

The avian Rev-T retrovirus encodes the v-Rel oncoprotein, which is a member of the Rel/NF-κB transcription factor family. v-Rel induces a rapidly fatal lymphoma/leukemia in young birds, and v-Rel can transform and immortalize a variety of avian cell types in vitro. Although Rel/NF-κB transcription factors have been associated with oncogenesis in mammals, v-Rel is the only member of this family that is frankly oncogenic in animal model systems. The potent oncogenicity of v-Rel is the consequence of a number of mutations that have altered its activity and regulation: for example, certain mutations decrease its ability to be regulated by IκBα, change its DNA-binding site specificity, and endow it with new transactivation properties. The study of v-Rel will continue to increase our knowledge of how cellular Rel proteins contribute to oncogenesis by affecting cell growth, altering cell-cycle regulation, and blocking apoptosis. This review will discuss biological and molecular activities of v-Rel, with particular attention to how these activities relate to structure – function aspects of the Rel/NF-κB transcription factors.

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Acknowledgements

I thank HR Bose Jr, C Gélinas, M Hannink, R Hrdlicková, and members of my laboratory for critical reading of the manuscript. I also thank C Cormier for help with literature research. Research in my laboratory on v-Rel is currently supported by grants from the NIH (CA47763) and the Council for Tobacco Research.

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Gilmore, T. Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene 18, 6925–6937 (1999). https://doi.org/10.1038/sj.onc.1203222

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