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Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

International Journal of Obesity volume 25, pages 1108–1112 (2001)Cite this article

Abstract

OBJECTIVE: To investigate the effect of an exercise training program on lipid profile in correlation with DHEA level and body weight and body composition in type 2 diabetic men.

DESIGN: Longitudinal, controlled clinical intervention study with exercise training consisting of an 8 week supervised program of aerobic exercise (75% VO2 peak, 45 min), twice a week and intermittent exercise, once a week, on a bicyle ergometer.

SUBJECTS: Sixteen men (age 45.4±7.2 y (mean±s.d.), HbA1c 8.15±1.7%, body mass index (BMI) 29.6±4.6 kg/m2) were randomly divided into two groups: trained group (n=8) and control group (n=8).

MEASUREMENTS: Lipid, apo- and lipoprotein and DHEA concentrations. Cross-sectional areas of subcutaneous and visceral adipose tissue and mid-thigh muscle by magnetic resonance imaging.

RESULTS: Training decreased visceral (153.25±38.55 vs 84.20±21.30 cm2, P<0.001), subcutaneous (241.55±49.55 vs 198.00±39.99 cm2, P<0.001) adipose tissue area and triglyceride levels (2.59±1.90 vs 1.79±1.08 nmol/l, P<0.05) and increased mid-thigh muscle cross-sectional area (148.30±36.10 vs 184.35±35.85 cm2, P<0.001), and DHEA levels (11.00±3.10 vs 14.25±4.10 nmol/l, P<0.05) with no modification in body weight. Changes in triglycerides were negatively correlated with changes in DHEA (r=−0.81, P=0.03). This correlation was independent of changes in abdominal fat distribution.

CONCLUSION: Training decreases abdominal fat depots, improves muscular mass and affects favourably triglyceride and DHEA levels. Changes in triglycerides and DHEA were inversely related.

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  1. Departments of Hormonal Biology, Radiology, Biochemistry B and Diabetology, Saint-Louis University Hospital, Paris, France

    P Boudou, E de Kerviler, D Erlich, P Vexiau & J-F Gautier

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  1. P Boudou
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Boudou, P., de Kerviler, E., Erlich, D. et al. Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes. Int J Obes 25, 1108–1112 (2001). https://doi.org/10.1038/sj.ijo.0801637

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