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Schematic depicting the preparation of a dual-responsive nanoparticle BCGN and its mechanisms in treating non-small-cell lung cancer (NSCLC). The BCGN are responsive to oxidation and reduction for triggering drug release at different conditions. It provides a promising strategy to improve combinational molecular targeted therapy against NSCLC.
Nucleus-targeting hybrid peptides obtained by fusing LTX-315 with rhodamine B inflicted DNA double-strand break (DSB)-mediated intrinsic apoptosis by destroying the nuclear membrane and inducing the accumulation of reactive oxygen species (ROS) in the nucleus.