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The use of the sex pheromone as an evolutionary solution to food source selection in caterpillars
Sex pheromones are used by adult members of a species to attract a mate. This study proposes that the larvae of the cotton leafwormSpodoptera littoralisare attracted to sex pheromones and prefer a food source containing it, suggesting an alternative use of the sex pheromone to trigger food search in caterpillars.
- Erwan Poivet
- , Kacem Rharrabe
- & Emmanuelle Jacquin-Joly
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Structured neuronal encoding and decoding of human speech features
Speech is encoded by the firing patterns of speech-controlling neurons in different regions of the brain, which Tankus and colleagues analyse in this study. They find highly specific encoding of vowels in medial–frontal neurons and nonspecific tuning in superior temporal gyrus neurons.
- Ariel Tankus
- , Itzhak Fried
- & Shy Shoham
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Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo
The amyloid beta peptide can aggregate into insoluble plaques, which may indicate the onset of Alzheimer's disease. In a mouse model of Alzheimer's disease, Cao and colleagues report a phenotype of altered connectivity in the olfactory neuronal circuit that precedes amyloid plaque deposition.
- Luxiang Cao
- , Benjamin R. Schrank
- & Mark W. Albers
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| Open AccessPINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
The kinase PINK1 is mutated in Parkinson's disease and accumulates in defective mitochondria, where it recruits Parkin. Here, PINK1 is shown to be autophosphorylated and this is required for the localization of PINK1 to mitochondria with a reduced membrane potential, and for the recruitment of Parkin.
- Kei Okatsu
- , Toshihiko Oka
- & Noriyuki Matsuda
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Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation
Changes in gene expression in the hippocampus and the cortex are pivotal for memory consolidation. Gräff and colleagues use a recognition task in mice to show that epigenetic post-translational modifications are rapidly activated in the hippocampus after learning, but induced with a delay in the cortex.
- Johannes Gräff
- , Bisrat T. Woldemichael
- & Isabelle M. Mansuy
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Gating of cyclic nucleotide-gated channels is voltage dependent
Cyclic nucleotide-gated channels are apparently voltage insensitive despite having the S4-type voltage sensor. Marchesiet al.show that the gating of wild-type CNGA1 and native CNG channels is voltage-independent in the presence of Li+, Na+ and K+, but that it is voltage-dependent in the presence of Rb+, Cs+ and organic cations.
- Arin Marchesi
- , Monica Mazzolini
- & Vincent Torre
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| Open AccessUnfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation
The protein OASIS belongs to the CREB/ATF transcription factor family and is involved in endoplasmic reticulum stress responses. Saito and colleagues show that these stress responses temporally activate OASIS in neural precursor cells, resulting in their differentiation into astrocytes.
- Atsushi Saito
- , Soshi Kanemoto
- & Kazunori Imaizumi
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| Open AccessHigh-performance and site-directed in utero electroporation by a triple-electrode probe
In uteroelectroporation allows the labelling of specific populations of neurons in the developing mouse brain. The authors of this paper present a simple modification of this method that increases labelling efficiency and allows, for the first time, transfection of Purkinje cells in the rat cerebellum.
- Marco dal Maschio
- , Diego Ghezzi
- & Laura Cancedda
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Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks
The cerebellum has important roles in motor control and sensory perception. Sultan and colleagues use electrical stimulation and functional magnetic resonance imaging to reveal that the cerebellum provides inputs to specialized cortical regions of the brain that modulate cerebro-cortical processing.
- Fahad Sultan
- , Mark Augath
- & Peter Thier
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| Open AccessMicroscopic magnetic stimulation of neural tissue
Electrical stimulation is used to treat a range of neurological diseases, but there are limitations that reduce its benefits. Bonmassar and colleagues show that magnetic stimulation delivered by small coils, close to the targeted neural tissue, can also be used to activate neurons and with fewer limitations.
- Giorgio Bonmassar
- , Seung Woo Lee
- & John T. Gale
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| Open AccessNeuronal influence on peripheral circadian oscillators in pupal Drosophila prothoracic glands
In the fruit flyDrosophila, changes in expression of circadian clock genes are believed to control eclosion. Morioka and colleagues show that transcriptional oscillations of the clock gene, period, in prothoracic gland cells are amplified by photic inputs from the central nervous system.
- Eri Morioka
- , Akira Matsumoto
- & Masayuki Ikeda
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| Open AccessSynGAP isoforms exert opposing effects on synaptic strength
Synaptic GTPase-activating protein, SynGAP, is a postsynaptic signalling protein that can regulate synaptic function. McMahonet al. express different SynGAP isoforms in neurons and find that the effect on synaptic strength depends on alternative promoter usage and alternative splicing of the C-terminus.
- A.C. McMahon
- , M.W. Barnett
- & P.C. Kind
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| Open AccessTargeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury
Claudin-5 is a component of tight junctions and has important roles in mediating the permeability of the blood-brain barrier. Campbell and co-workers administer short interfering RNA against claudin-5 in a model of brain injury, finding that it enhances water movement from the brain to the blood and alleviates swelling.
- Matthew Campbell
- , Finnian Hanrahan
- & Peter Humphries
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| Open AccessActivin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors
Signalling inputs to neural progenitors regulate the differentiation of the stem cell pool. By analysing the mechanisms occuring during neurogenesis, Cambrayet al. report that activin is the pivotal factor regulating the differentiation of telencephalic neural precursors towards a cortical interneuron fate.
- Serafí Cambray
- , Charles Arber
- & Tristan A. Rodríguez
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Environmental noise exposure degrades normal listening processes
The damaging effects of loud noise on auditory function are well established, but the effects of low-level noise are not so well understood. Zhou and Merzenich chronically expose adult rats to structured low-level noise and find that it causes auditory cortex damage and sound discrimination impairment.
- Xiaoming Zhou
- & Michael M. Merzenich
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| Open AccessThe Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2
Mitochondrial dynamics and trafficking are important for providing energy for neuron function. In this study, the Armadillo repeat containing proteins clustered on the X chromosome are shown to be highly expressed in the nervous system and have a role in mitochondrial dynamics.
- Guillermo López-Doménech
- , Román Serrat
- & Eduardo Soriano
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Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila
Adars are adenosine deaminases that act on RNAs, including those encoding proteins involved in neuronal transmission and also Adar RNA. Here, Savvaet al. engineered knock-in Drosophila mutants with altered Adar autoediting and found that this changed the spectrum of adenosine deamination and Drosophilabehaviour.
- Yiannis A. Savva
- , James E.C Jepson
- & Robert A. Reenan
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Auditory cortex of newborn bats is prewired for echolocation
Bats use a process known as echolocation to measure the distance of an object by echo delay. Here, studies in newborn bats reveal that echo delay tuning of neurons in the auditory cortex is present at birth rather than acquired as a result of echolocation experience.
- Manfred Kössl
- , Cornelia Voss
- & Marianne Vater
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Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
The loss of neurotrophic factors is responsible for key neurodegenerative processes in Alzheimer's disease. In this study, Obregon and colleagues treat amyloidogenic cells with the neurotrophin soluble amyloid precursor protein-α and find that it halts amyloidogenesis by interacting with the β-secretase BACE1.
- Demian Obregon
- , Huayan Hou
- & Jun Tan
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| Open AccessStaged decline of neuronal function in vivo in an animal model of Alzheimer's disease
The amyloid-β-peptide is pivotal to the pathology of Alzheimer's disease, but its mechanism of action remains uncertain. This study utilizesin vivotwo-photon calcium imaging to investigate the effects of this peptide on single cortical neurons of the visual cortex in a mouse model of Alzheimer's disease.
- Christine Grienberger
- , Nathalie L. Rochefort
- & Arthur Konnerth
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Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation
Animals sense multiple environmental cues simultaneously and use this sensory information to regulate feeding behaviour, which is fundamental to survival. Li and co-workers describe a central circuit inCaenorhabditis elegansthat can be activated by attractive odours or repellents to facilitate or suppress feeding behaviour.
- Zhaoyu Li
- , Yidong Li
- & Tao Xu
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| Open AccessNeural circuits in the brain that are activated when mitigating criminal sentences
Jurors can be influenced by mitigating circumstances when deciding on sentences for committed crimes. Yamadaet al. show that feelings of sympathy created by mitigating circumstances activate moral conflict regions of the brain that predict individual differences in the severity of the sentence.
- Makiko Yamada
- , Colin F. Camerer
- & Hidehiko Takahashi
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Transient activation of specific neurons in mice by selective expression of the capsaicin receptor
The ability to spatially and temporally control excitation of neuronsin vivo is an invaluable tool. By expressing the TRPV1 receptor in specific neuronal populations, Güler et al. have developed a rapid and noninvasive method to stimulate neuronal activity by the simple administration of capsaicin.
- Ali D. Güler
- , Aundrea Rainwater
- & Richard D. Palmiter
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| Open AccessIntracellular chloride concentration influences the GABAA receptor subunit composition
During development there is a change in the expression of GABAA receptor subunits. Here, Succol and colleagues show that chloride ions mediate the change in α3-α1 and δ-containing GABAAreceptors that mediate phasic and tonic inhibition, respectively.
- Francesca Succol
- , Hubert Fiumelli
- & Andrea Barberis
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Odour concentration-dependent olfactory preference change in C. elegans
Some animals find the same odorant attractive at low concentrations and repulsive at high concentrations, but how this discrimination occurs is unclear. UsingCaenorhabditis elegans as a model system, Yoshida et al. show that different sets of sensory neurons respond to low and high concentrations of odours.
- Kazushi Yoshida
- , Takaaki Hirotsu
- & Takeshi Ishihara
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| Open AccessSUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair
Tyrosyl DNA phosphodiesterase 1 (TDP1) repairs DNA breaks and is mutated in the disease Spinocerebellar Ataxia with Axonal Neuropathy. Here TDP1 is shown to be post-translationally modified by sumoylation of lysine 111, and cells carrying a mutation at this residue are inefficient at single-strand DNA break repair.
- Jessica J.R. Hudson
- , Shih-Chieh Chiang
- & Sherif F. El-Khamisy
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| Open AccessLIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites
Maturation of synaptic junctions is important for proper neuronal connections. Using live cell imaging, Okabeet al. show that interneuron dendrites extend filopodia-like projections and use microtubule-dependent retrograde transport to guide proper synaptic distribution on dendrites.
- Izumi Kawabata
- , Yutaro Kashiwagi
- & Shigeo Okabe
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| Open AccessStructure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
The pentameric ligand gated ion channel fromErwinia chrysanthemi(ELIC) is similar in structure to the nicotinic acetylcholine receptor, a member of the Cys-loop receptor family. This study reports the crystal structure of ELIC bound to acetylcholine and shows that acetylcholine is a competitive antagonist of ELIC.
- Jianjun Pan
- , Qiang Chen
- & Pei Tang
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| Open Accessγ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor
Glutathione's key role as a modulator of reactive oxygen species levels has recently been challenged. Quintana-Cabreraet al. now provide in vivoevidence supporting an antioxidant and neuroprotective function for γ-glutamylcysteine, which replaces glutathione by acting as glutathione peroxidase-1 cofactor.
- Ruben Quintana-Cabrera
- , Seila Fernandez-Fernandez
- & Juan P. Bolaños
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The impact of asymmetrical light input on cerebral hemispheric specialization and interhemispheric cooperation
Lateralization of the brain can provide evolutionary advantages by enhancing behavioural and cognitive capacities. Manns and Römling confirm that lateralized environmental experience in pigeons induces hemispheric specialization and show that this affects the efficiency of interhemispheric crosstalk.
- Martina Manns
- & Juliane Römling
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Network physiology reveals relations between network topology and physiological function
Humans are a network of complex physiological systems, but quantifying these diverse systems is a challenge. This study presents a method to show that each physiological state is characterized by a specific network structure, demonstrating a connection between network topology and function.
- Amir Bashan
- , Ronny P. Bartsch
- & Plamen Ch. Ivanov
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Ultra-rapid access to words in the brain
The exact speed of spoken word processing by our brain is still unknown. Using MEG to compare brain responses to words and pseudowords, MacGregoret al. show that lexical processing occurs 50 ms after acoustic information is presented, suggesting that our brain's access to word information is near-instantaneous.
- Lucy J MacGregor
- , Friedemann Pulvermüller
- & Yury Shtyrov
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Rats track odour trails accurately using a multi-layered strategy with near-optimal sampling
Animals track odour trails to find food, a mate or to steer clear of danger. Bhalla and colleagues combine behavioural and physiological measurements to show that rats can track surface-borne odours with near-optimal sampling and are able to predict the path direction on encountering a bifurcation.
- Adil Ghani Khan
- , Manaswini Sarangi
- & Upinder Singh Bhalla
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Humans and chimpanzees attend differently to goal-directed actions
Humans understand actions by making inferences about the person's intentions. Comparing humans with chimpanzees, this study shows that humans refer to the actors' faces more than chimpanzees do when observing goal-directed actions, indicating that humans view actions by integrating information from the actor.
- Masako Myowa-Yamakoshi
- , Céline Scola
- & Satoshi Hirata
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Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high intermediate progenitors
Neural stem cells generate neurons in the adult hippocampus, but the dynamics of neuron production remain unclear. This study shows that stem cells produce type-2a progenitors, which do not expand as previously thought, but rather generate amplifying immature neuroblasts.
- Sebastian Lugert
- , Miriam Vogt
- & Verdon Taylor
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| Open AccessExistence of long-lasting experience-dependent plasticity in endocrine cell networks
Experience-dependent plasticity and functional adaptation are thought to be restricted to the central nervous and immune systems. This study shows that long-lasting experience-dependent plasticity is a key feature of endocrine cell networks, allowing improved tissue function and hormone output following repeat demand.
- David J. Hodson
- , Marie Schaeffer
- & Patrice Mollard
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Rapid adaptation to food availability by a dopamine-mediated morphogenetic response
Food availability elicits behavioural and developmental responses. Adamset al. show that, in sea urchin larvae, food availability mediates developmental plasticity by regulating changes in arm length through dopamine signalling, a pathway widely used to mediate food-induced behavioural responses.
- Diane K. Adams
- , Mary A. Sewell
- & Lynne M. Angerer
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| Open AccessReinforcement learning in professional basketball players
Reinforcement learning quantifies the change in behaviour in response to past experience. Using field goal attempt data from basketball, Neiman and Loewenstein demonstrate that even one failed or made attempt has an impact on subsequent attempts, showing that players overgeneralize from their most recent actions.
- Tal Neiman
- & Yonatan Loewenstein
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| Open AccessDendritic spine formation and synaptic function require neurobeachin
Most excitatory synapses in the brain are found on dendritic spines, but the mechanisms underlying synapse formation are poorly understood. Niesmannet al. investigate the role of neurobeachin in synaptogenesis, and find that its deletion leads to fewer spinous synapses and altered postsynaptic currents.
- Katharina Niesmann
- , Dorothee Breuer
- & Markus Missler
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TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol
TRPA1 is a key ion channel in pain signalling. This study shows that activation of TRPA1 in the spinal cord by acetaminophen metabolites and a non-electrophilic cannabinoid produces antinociception that is lost in mice lacking TRPA1, providing an explanation for the analgesic activity of acetaminophen.
- David A Andersson
- , Clive Gentry
- & Peter M Zygmunt
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Genetic dissection of axon regeneration via in vivo electroporation of adult mouse sensory neurons
Dorsal root ganglion neurons can regenerate after injury, but the mechanisms underlying axon regrowth are unclear. To address this, an electroporation transfection method is developed that can alter the gene expression of dorsal root ganglion cells in a living adult mouse, providing a tool to study axon regeneration.
- Saijilafu
- , Eun-Mi Hur
- & Feng-Quan Zhou
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Tactile stimulation lowers stress in fish
The health benefits of massage therapy, like the reduction of stress, have so far only been shown in humans. This study uses modelling to demonstrate that, while visiting cleaner fish to have ectoparasites removed, the physical stimulation also acts to reduce stress in the coral reef fish,Ctenochaetus striatus.
- Marta C. Soares
- , Rui F. Oliveira
- & Redouan Bshary
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| Open AccessExtrasynaptic vesicle recycling in mature hippocampal neurons
In the classical model, fast neuronal signalling occurs at specialized presynaptic terminals. Now, Ratnayakaet al. show that stimulus-driven fusion and recycling of synaptic vesicles can occur at axonal sites remote from conventional synapses. These findings have implications for dynamic forms of neuron–neuron communication.
- Arjuna Ratnayaka
- , Vincenzo Marra
- & Kevin Staras
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Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision
At light levels where both rods and cones are active, their signals converge into shared downstream retinal circuitry. Using HCN1 deficient mice, this study shows that the signals from cone photoreceptors are overwhelmed when rod output is not regulated, suggesting a mechanism for how these systems interact.
- Mathias W. Seeliger
- , Arne Brombas
- & Frank Müller
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miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
The microRNA miR-137 is enriched in the brain of mice and induces the differentiation of adult neural stem cells. Now, Sun and colleagues report that miR-137 negatively regulates proliferation of neurons in embryonic mice and that TLX and LSD1 cooperate to negatively regulate miR-137 expression, blocking premature differentiation.
- GuoQiang Sun
- , Peng Ye
- & Yanhong Shi
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Review Article |
Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction
Hair cells of the inner ear transduce vibrations of the basilar membrane into electrical signals by a process known as mechanotransduction. Recent advances in genetic and molecular tools have led to an improved understanding of mechanotransduction as Peng and colleagues summarize in this Review.
- Anthony W. Peng
- , Felipe T. Salles
- & Anthony J. Ricci
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Synapse microarray identification of small molecules that enhance synaptogenesis
Large scale synapse assays can facilitate identification of drug leads. Shiet al. develop a 'synapse microarray' technology that enables sensitive, high-throughput, quantitative screening of synaptogenic events, and use it to identify novel histone deacetylase inhibitors that enhance synaptogenesis.
- Peng Shi
- , Mark A. Scott
- & Mehmet Fatih Yanik
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Behavioural memory reconsolidation of food and fear memories
Memory retrieval followed by extinction training has been shown to erase fear memories. Flavellet al. show that this approach also erases appetitive memories in rats and results from a modification of memory reconsolidation, which could be useful for the treatment of drug addiction.
- Charlotte R. Flavell
- , David J. Barber
- & Jonathan L.C. Lee
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NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers
In non-NMDA glutamate receptors, intersubunit contacts within agonist binding domains affect functional desensitization. Now, NMDA receptor activation, but not desensitization, is shown to involve rearrangements at the heterodimer interface, suggesting that the intersubunit contacts of NMDA and non-NMDA receptors may have distinct functional roles.
- William F. Borschel
- , Swetha E. Murthy
- & Gabriela K. Popescu
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