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| Open AccessLarval microbiota primes the Drosophila adult gustatory response
How the larval environment influences the sensory characteristics of the future adult is largely unknown. Here, using Drosophila as a model, the authors show that the presence of certain bacterial species during the larval stage modify the gustatory capacities of the future adult flies.
- Martina Montanari
- , Gérard Manière
- & Julien Royet
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| Open AccessA neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila
The valence of information about food sources can be conflicting. Here, the authors show that activity in a small population of neurons projecting to the fan-shaped body of Drosophila represents food choice during sensory conflict.
- Preeti F. Sareen
- , Li Yan McCurdy
- & Michael N. Nitabach
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| Open AccessThe insulo-opercular cortex encodes food-specific content under controlled and naturalistic conditions
Animal studies have shown that insulo-opercular network function is critical in gustation and in behaviour based on anticipated food availability. The authors describe activities within the human insulo-opercular cortex which underlie anticipatory food evaluation in both controlled and naturalistic settings.
- Yuhao Huang
- , Bina W. Kakusa
- & Casey H. Halpern
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| Open AccessSatb2 neurons in the parabrachial nucleus mediate taste perception
The genetic identity of taste-responsive neurons has not been determined. The authors describe neurons in the gustatory region of the parabrachial nucleus that express the transcription factor Satb2, project to taste-associated regions, and modulate taste preferences.
- Brooke C. Jarvie
- , Jane Y. Chen
- & Richard D. Palmiter
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| Open AccessHypothalamic neuronal circuits regulating hunger-induced taste modification
Hunger modulates perception of good and bad tastes. Here, the authors report that orexigenic AgRP neurons in the hypothalamus mediate these effects through glutamatergic lateral hypothalamic neurons that send distinct projections to the lateral septum and lateral habenula.
- Ou Fu
- , Yuu Iwai
- & Ken-ichiro Nakajima
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| Open AccessDistinct representations of basic taste qualities in human gustatory cortex
Previous research shows how taste types are represented across regions of the brain in non-human animals. Here, the authors examine how four basic tastes are represented in the human brain, showing evidence of the human gustatory cortex in the insula.
- Junichi Chikazoe
- , Daniel H. Lee
- & Adam K. Anderson
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| Open AccessHeterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds
Taste sensilla are Drosophila sensory organs containing taste neurons, which have differential tuning for bitter compounds. Here, the authors systematically examine what combinations of gustatory receptor genes confer a specific taste response profile in different bitter taste neurons.
- Ha Yeon Sung
- , Yong Taek Jeong
- & Seok Jun Moon
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| Open AccessTranscriptomes and neurotransmitter profiles of classes of gustatory and somatosensory neurons in the geniculate ganglion
Characterization of gustatory neural pathways has suffered due to a lack of molecular markers. Here, the authors report single cell RNA sequencing and unbiased transcriptome analyses to reveal major distinctions between gustatory and somatosensory neurons and subclusters of gustatory neurons with unique molecular and functional profiles.
- Gennady Dvoryanchikov
- , Damian Hernandez
- & Nirupa Chaudhari
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| Open AccessStructural basis for perception of diverse chemical substances by T1r taste receptors
Nutrients taste perception is mediated by T1r receptors that discriminate specific tastes among their wide diversity. Here the authors present crystal structures of the ligand-binding domains of the fish T1r2-T1r3 receptor, providing a structural framework for its ligand recognition.
- Nipawan Nuemket
- , Norihisa Yasui
- & Atsuko Yamashita
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| Open AccessA mechanosensory receptor required for food texture detection in Drosophila
The cellular and molecular mechanisms underlying food texture detection are poorly understood. Here the authors show thatDrosophilacan discriminate food texture when feeding, and that this ability depends on NOMPC, a mechanosensory channel expressed in gustatory sensilla neurons.
- Juan Antonio Sánchez-Alcañiz
- , Giovanna Zappia
- & Richard Benton
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| Open AccessMechanosensory neurons control sweet sensing in Drosophila
How different sensory modalities interact to control feeding is poorly understood. Here, authors show that in Drosophila, activation of labellar mechanosensory neurons causes inhibition of sweet-sensing gustatory receptor neurons, as a result, Drosophilaprefer soft food at the expense of sweetness.
- Yong Taek Jeong
- , Soo Min Oh
- & Seok Jun Moon
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| Open AccessCentral relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain
Bitter taste evokes aversive behaviour in animals, but little is known about the central nervous system mechanisms that convey this taste modality. Hückesfeld et al. identify a set of second order neurons in Drosophilathat contain hugin neuropeptide and are responsible for conveying bitter taste to the protocerebrum.
- Sebastian Hückesfeld
- , Marc Peters
- & Michael J. Pankratz
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| Open AccessFunctional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila
Locating food sources is essential for the survival of animals. Here, the authors identify two functionally and anatomically distinct classes of sweet taste receptor neurons in Drosophila legs, involved in feeding initiation and sugar-dependent suppression of locomotion.
- Vladimiros Thoma
- , Stephan Knapek
- & Hiromu Tanimoto
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| Open AccessMultimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae
While gustatory systems have been extensively studied in adult Drosophila, not much is known about taste coding at the larval stage. Here, the authors investigate gustatory receptor neurons in larvae and find single neurons are capable of responding to more than one taste modality.
- Lena van Giesen
- , Luis Hernandez-Nunez
- & Simon G. Sprecher
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| Open AccessThe full repertoire of Drosophila gustatory receptors for detecting an aversive compound
It remains unclear whether any set of the 68 gustatory receptors expressed in Drosophilacomprise a cation channel that responds to an aversive chemical. Here the authors identify three gustatory receptors that are both necessary and sufficient to form a channel that confers sensitivity to a noxious tastant.
- Jaewon Shim
- , Youngseok Lee
- & Seok Jun Moon
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| Open AccessBreadth of tuning in taste afferent neurons varies with stimulus strength
How taste information is encoded and transmitted from the periphery to the cortex is not well understood. Here the authors provide evidence for population-based coding of taste by demonstrating that more than half of individual geniculate ganglion neurons are broadly tuned to basic taste stimuli.
- An Wu
- , Gennady Dvoryanchikov
- & Stephen D. Roper
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Pharyngeal sense organs drive robust sugar consumption in Drosophila
Sweet taste plays a key role in promoting ingestion of nutritionally rich sources of carbohydrates. Here, the authors demonstrate that the pharyngeal sense organs in adult Drosophilaare important for directing the sustained consumption of sweet compounds.
- Emily E. LeDue
- , Yu-Chieh Chen
- & Michael D. Gordon
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A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning
Insect gustatory and olfactory receptor genes encode transmembrane proteins that detect diverse chemicals, but their evolutionary origins are unclear. This study identifies homologues of these genes in non-Bilateria and reveals an unexpected role for one in sea anemone embryonic development.
- Michael Saina
- , Henriette Busengdal
- & Richard Benton
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Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans
Salt chemotaxis behaviour inCaenorhabditis elegansis partly dependent on previous experiences of starvation. In this study, the authors show that this learned behaviour is due to experience-dependent plasticity in a subset of gustatory neurons.
- Hirofumi Kunitomo
- , Hirofumi Sato
- & Yuichi Iino
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Acid sensing by sweet and bitter taste neurons in Drosophila melanogaster
Taste detection in Drosophila melanogasterhas been well characterized for bitter and sweet stimuli. In this study, the authors characterize taste detection for acids and find that they are detected by a subset of bitter taste neurons, and that they inhibit the responses of sweet-sensing neurons to sugar.
- Sandhya Charlu
- , Zev Wisotsky
- & Anupama Dahanukar