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Measles virus fusion shifts into gear

Nature Structural & Molecular Biology volume 18, pages 115–116 (2011)Cite this article

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In this issue, two papers present contrasting models for the machinations of the measles virus attachment protein. Here we discuss how these reports illuminate possible intersubunit motions made by the protein as it drives the fusion of viral and cellular membranes during infection and further our understanding of this global scourge.

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Figure 1: Schematics for conformational changes in MV-H that trigger membrane fusion.

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Acknowledgements

This work was supported by US National Institutes of Health grants AI009484, AI045927 and AI070967 (M.B.A.O.) and AI067927, AI082156, AI081982, AI070530, AI088843, HSSN27220090049C, AI089498; by an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund; and by The Skaggs Institute for Chemical Biology (E.O.S.). This work may be cross-referenced as Publication Number 21032 from the Department of Immunology and Microbial Science at The Scripps Research Institute.

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  1. Erica Ollmann Saphire and Michael B. A. Oldstone are in the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,

    Erica Ollmann Saphire & Michael B A Oldstone

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  1. Erica Ollmann Saphire
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  2. Michael B A Oldstone
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Correspondence to Erica Ollmann Saphire or Michael B A Oldstone.

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Saphire, E., Oldstone, M. Measles virus fusion shifts into gear. Nat Struct Mol Biol 18, 115–116 (2011). https://doi.org/10.1038/nsmb0211-115

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