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A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia
- Sophie Edtmayer
- , Agnieszka Witalisz-Siepracka
- & Dagmar Stoiber
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Article
| Open Access
PICK1 inhibits the malignancy of nasopharyngeal carcinoma and serves as a novel prognostic marker
- Xiaomin Ou
- , Yingzi Zhang
- & Yong Liu
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| Open Access
PDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway
- Yuanzhen Ma
- , Zhiyu Fang
- & Junfang Zheng
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| Open Access
SPOP point mutations regulate substrate preference and affect its function
- Yanran Deng
- , Wenhao Ding
- & Ligong Lu
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| Open Access
Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth
- Yong Zuo
- , Jiawei Bai
- & Yan-Zhong Chang
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| Open Access
The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
- Yangyang Feng
- , Ming Zhao
- & Chu-Xia Deng
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Article
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TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
- Donghee Kang
- , Hyun Jung Hwang
- & Jae-Seon Lee
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Article
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Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma
- Xiaoping Zhang
- , Yong Zhong
- & Zhongwei Lv
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Article
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Blockade of DDR1/PYK2/ERK signaling suggesting SH2 superbinder as a novel autophagy inhibitor for pancreatic cancer
- Hui Xu
- , Ming Tan
- & An-Dong Liu
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Article
| Open Access
ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape
- Tianyao Liu
- , Xinyan Xu
- & Rong Yang
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Article
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Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse
- Jiabing Li
- , Shujun Xiao
- & Min Lu
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Article
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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments
- Takeru Torii
- , Wataru Sugimoto
- & Keiko Kawauchi
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Article
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The p53/ZEB1-PLD3 feedback loop regulates cell proliferation in breast cancer
- Bo-Wen Liu
- , Ning Sun
- & Yue Yu
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Article
| Open Access
RBMS3-induced circHECTD1 encoded a novel protein to suppress the vasculogenic mimicry formation in glioblastoma multiforme
- Xuelei Ruan
- , Yunhui Liu
- & Xiaobai Liu
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Article
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FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
- Ganesh Kumar Barik
- , Osheen Sahay
- & Manas Kumar Santra
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Article
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N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer
- Rebecca Yun
- , Eunji Hong
- & Jin Muk Kang
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Article
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Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC
- Wei Xue
- , Wengang Jian
- & Cheng Zhang
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Article
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TRIM26 inhibited osteosarcoma progression through destabilizing RACK1 and thus inactivation of MEK/ERK signaling
- Kezhou Xia
- , Di Zheng
- & Weichun Guo
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Article
| Open Access
Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
- Yue Wu
- , Yuansheng Duan
- & Chao Jing
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Article
| Open Access
WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer
- Tianqi Liu
- , Min Zhao
- & Xiangqian Su
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Article
| Open Access
Epigenetically modified AP-2α by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression
- Shengwen Long
- , Guixiang Huang
- & Xiaofeng Ding
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Article
| Open Access
ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylation
- Wuping Yang
- , Zedan Zhang
- & Kan Gong
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Article
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FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2
- Rafael Jiménez-Izquierdo
- , Rosario Morrugares
- & Marco A. Calzado
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Article
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Regulation of immunological tolerance by the p53-inhibitor iASPP
- Elliot H. Akama-Garren
- , Paul Miller
- & Xin Lu
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Article
| Open Access
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine
- Mireia Palomar-Siles
- , Angelos Heldin
- & Klas G. Wiman
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Article
| Open Access
USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling
- Wen-ya Huang
- , Zhi-bin Liao
- & Ke-shuai Dong
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Article
| Open Access
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity
- Ruru Wang
- , Yajing Shang
- & Guoping Zhao
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Article
| Open Access
TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation
- Min Soo Kim
- , Won Sung Lee
- & Wook Jin
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Article
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MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer
- Yujing Gao
- , Yujie Fang
- & Pu Li
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Review Article
| Open Access
An update regarding the role of WNK kinases in cancer
- Mengxi Xiu
- , Li Li
- & Yong Gao
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Article
| Open Access
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation
- Xuehui Wang
- , Wei Jian
- & Lin Fang
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Article
| Open Access
NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3
- Yuanping Zhang
- , Dinglan Zuo
- & Binkui Li
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Article
| Open Access
XAF1 drives apoptotic switch of endoplasmic reticulum stress response through destabilization of GRP78 and CHIP
- Kyung-Woo Lee
- , Hui-Ra Hong
- & Sung-Gil Chi
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Article
| Open Access
AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis
- Hyunjoo Kim
- , Muhah Jeong
- & Yong-Keun Jung
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Article
| Open Access
UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer
- Gang Xiang
- , Shuxuan Wang
- & Jing Yu
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Article
| Open Access
The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions
- Madeleine Eichler
- , Ute Distler
- & Gergely Imre
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Article
| Open Access
MFSD4A inhibits the malignant progression of nasopharyngeal carcinoma by targeting EPHA2
- Huiyun Yang
- , Guanjie Qin
- & Wei Jiang
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Article
| Open Access
SorCS3 promotes the internalization of p75NTR to inhibit GBM progression
- Yanqiu Zhang
- , Yue Li
- & Dongliang Li
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Article
| Open Access
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
- Qiang Zhang
- , Dimitrios-Ilias Balourdas
- & Andreas C. Joerger
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Article
| Open Access
Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer
- Weiwei Sheng
- , Jingtong Tang
- & Ming Dong
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Article
| Open Access
Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway
- Caie Wang
- , Na Gao
- & Hailing Qiao
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Article
| Open Access
MiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1
- Zhe-bin Dong
- , Heng-miao Wu
- & Wei Chen
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Article
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CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to-mesenchymal transition
- Dandan Li
- , Jiawei Zhang
- & Rui Zhang
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Article
| Open Access
ZBTB38 suppresses prostate cancer cell proliferation and migration via directly promoting DKK1 expression
- Guanxiong Ding
- , Wei Lu
- & Jianqing Wang
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Article
| Open Access
p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway
- Yitian Guo
- , Melanie Rall-Scharpf
- & Stephanie Biber
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Article
| Open Access
p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress
- Lin Tze Tung
- , HanChen Wang
- & Anastasia Nijnik
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Article
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TRAIL-receptor 2—a novel negative regulator of p53
- Anna Willms
- , Hella Schupp
- & Anna Trauzold
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Article
| Open Access
Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis
- Jun Wang
- , Holly R. Thomas
- & John M. Parant
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Article
| Open Access
VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway
- Ying Tong
- , Jinyan Kai
- & Renquan Lu
Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells