Time-lapse imaging articles within Nature Methods

Featured

  • Brief Communication |

    Live-cell volumetric super-resolution imaging with 120-nm lateral and 360-nm axial resolution using structured-illumination microscopy at speeds of up to 5 s per cell volume over >50 time points captures fine cellular dynamics using only low illumination intensities.

    • Lin Shao
    • , Peter Kner
    •  & Mats G L Gustafsson

  • Article |

    Incorporation of time information into the annotation of distinct biological states in automated fluorescence time-lapse live-cell imaging of complex cellular dynamics reduces both classification noise and confusion between cell states with similar morphology. A computational framework for achieving this is implemented in the open-source software package CellCognition.

    • Michael Held
    • , Michael H A Schmitz
    •  & Daniel W Gerlich

  • Research Highlights |

    Live-cell time-lapse imaging of somatic cells undergoing reprogramming raises interesting questions about the mechanism of the process.

    • Natalie de Souza

  • News & Views |

    Prospective isolation of defined cell types is a crucial prerequisite for their molecular analysis, but the heterogeneity of populations yielded by current protocols obscures relevant information. New studies now use additional features from time-resolved imaging data for live prospective identification of cells with defined future behavior.

    • Timm Schroeder

  • Article |

    The fates of cultured neural progenitor cells can be predicted by algorithmic information theory-based computational analysis of time-lapse images of the cells.

    • Andrew R Cohen
    • , Francisco L A F Gomes
    •  & Michel Cayouette

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