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| Open AccessMulti-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis
- Lingzi Li
- , Janina Freitag
- & Nadine Biesemann
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| Open AccessIn silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19
- Nabih A. Baeshen
- , Abdulaziz O. Albeshri
- & Mohammed N. Baeshen
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| Open AccessLabel-free prediction of cell painting from brightfield images
- Jan Oscar Cross-Zamirski
- , Elizabeth Mouchet
- & Yinhai Wang
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| Open AccessTranscriptional changes of biochemical pathways in Meloidogyne incognita in response to non-fumigant nematicides
- Catherine L. Wram
- , Cedar N. Hesse
- & Inga A. Zasada
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| Open AccessStructure-based assessment and druggability classification of protein–protein interaction sites
- Lara Alzyoud
- , Richard A. Bryce
- & Mohammad A. Ghattas
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| Open AccessIdentification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection
- Maria L. Faquetti
- , Francesca Grisoni
- & Andrea M. Burden
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| Open AccessImatinib inhibits SARS-CoV-2 infection by an off-target-mechanism
- Romano Strobelt
- , Julia Adler
- & Yosef Shaul
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| Open AccessIndole decreases the virulence of the bivalve model pathogens Vibrio tasmaniensis LGP32 and Vibrio crassostreae J2-9
- Shanshan Zhang
- , Qian Yang
- & Tom Defoirdt
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| Open AccessIn silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs
- Wallace K. B. Chan
- , Keith M. Olson
- & John R. Traynor
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| Open AccessMetabolomics-based profiling of 4 avocado varieties using HPLC–MS/MS and GC/MS and evaluation of their antidiabetic activity
- Inas Y. Younis
- , Amira R. Khattab
- & Mahitab H. El Bishbishy
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Article
| Open AccessNaturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer
- Sergio Enríquez-Flores
- , Luis A. Flores-López
- & Gabriel López-Velázquez
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| Open AccessPotential of [11C]UCB-J as a PET tracer for islets of Langerhans
- Emmi Puuvuori
- , Johanna Rokka
- & Olof Eriksson
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Article
| Open AccessCurcumin derivative ST09 modulates the miR-199a-5p/DDR1 axis and regulates proliferation and migration in ovarian cancer cells
- Febina Ravindran
- , Jinsha Koroth
- & Bibha Choudhary
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| Open AccessActivation of specific bitter taste receptors by olive oil phenolics and secoiridoids
- Meng Cui
- , Bohan Chen
- & Prokopios Magiatis
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Article
| Open AccessEstablishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1
- Kaizhao Hu
- , Xiao-Jing Li
- & Hong-Min Liu
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| Open AccessPrediction of severe adverse events, modes of action and drug treatments for COVID-19’s complications
- Courtney Astore
- , Hongyi Zhou
- & Jeffrey Skolnick
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Article
| Open AccessTargeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
- Marta Poblocka
- , Akang Leonard Bassey
- & Salvador Macip
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| Open AccessSingle-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis
- Zhong-Yi Wang
- , Adrian Keogh
- & Florian Nigsch
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Article
| Open AccessCurcumin inhibited hepatitis B viral entry through NTCP binding
- Piyanoot Thongsri
- , Yongyut Pewkliang
- & Khanit Sa-ngiamsuntorn
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Article
| Open AccessCellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy
- Nicholas D. Henkel
- , Marissa A. Smail
- & Rammohan Shukla
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Article
| Open AccessProlyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target
- Takeshi Yamamotoya
- , Yusuke Nakatsu
- & Takemasa Sakaguchi
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Article
| Open AccessA forward genetic screen identifies modifiers of rocaglate responsiveness
- Leo Shen
- , Lauren Pugsley
- & Jerry Pelletier
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Article
| Open AccessMechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica
- Vivek Dhar Dwivedi
- , Ankita Singh
- & Esam Ibraheem Azhar
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| Open AccessAn alcoholic extract of Thuja orientalis L. leaves inhibits autophagy by specifically targeting pro-autophagy PIK3C3/VPS34 complex
- Juneyoung Jung
- , Yoomi Chun
- & Joungmok Kim
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| Open AccessPhytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice
- Hongfei Ge
- , Gongxin Liu
- & Brandon Ason
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Article
| Open AccessSecretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells
- Mei Ding
- , Rajneesh Malhotra
- & Lovisa Holmberg Schiavone
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| Open AccessRapid target validation in a Cas9-inducible hiPSC derived kidney model
- Yasaman Shamshirgaran
- , Anna Jonebring
- & Ryan Hicks
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Article
| Open AccessExploring the selectivity of guanine scaffold in anticancer drug development by computational repurposing approach
- D. R. Sherin
- & T. K. Manojkumar
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| Open AccessTrendyGenes, a computational pipeline for the detection of literature trends in academia and drug discovery
- Guillermo Serrano Nájera
- , David Narganes Carlón
- & Daniel J. Crowther
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Article
| Open AccessProbing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine
- Jos J. A. Trentelman
- , Julen Tomás-Cortázar
- & Joppe W. Hovius
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Article
| Open AccessGlutamic acid promotes hair growth in mice
- Carlos Poblete Jara
- , Beatriz de Andrade Berti
- & Eliana Pereira Araújo
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| Open AccessDiscovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
- Hyunjong Lee
- , Jeongbin Park
- & Hongyoon Choi
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| Open AccessIdentification of anticancer drug target genes using an outside competitive dynamics model on cancer signaling networks
- Tien-Dzung Tran
- & Duc-Tinh Pham
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Article
| Open AccessAcyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro
- Eva Doleželová
- , Tomáš Klejch
- & Alena Zíková
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| Open AccessImpairing flow-mediated endothelial remodeling reduces extravasation of tumor cells
- Gautier Follain
- , Naël Osmani
- & Jacky G. Goetz
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| Open AccessGenetic dependency of Alzheimer’s disease-associated genes across cells and tissue types
- Suraj K. Jaladanki
- , Abdulkadir Elmas
- & Kuan-lin Huang
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Article
| Open AccessA novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus
- S. Kiruthika
- , Ruchika Bhat
- & B. Jayaram
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| Open AccessIn vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα
- Benjamin Xiaoyi Li
- , Xiangrong Dai
- & Heyu Ni
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Article
| Open AccessEvaluation method for asymmetric uncertainty of quantitative polymerase chain reaction measurements of deoxyribonucleic acids with low copy number
- Unoh Ki
- , Takeru Suzuki
- & Hirotaka Unno
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| Open AccessTargeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19
- Antonio Julià
- , Irene Bonafonte-Pardàs
- & Sara Marsal
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| Open AccessInsights of antiparasitic activity of sodium diethyldithiocarbamate against different strains of Trypanosoma cruzi
- Johny Wysllas de Freitas Oliveira
- , Taffarel Melo Torres
- & Marcelo Sousa Silva
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| Open AccessIn-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy
- Kolja Becker
- , Holger Klein
- & Remko A. Bakker
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| Open AccessRepurposing ketoconazole as an exosome directed adjunct to sunitinib in treating renal cell carcinoma
- Jacob W. Greenberg
- , Hogyoung Kim
- & Louis S. Krane
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| Open AccessRepurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase
- Syed Hani Abidi
- , Nahlah Makki Almansour
- & Syed Ali
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| Open AccessHighly specific and ultrasensitive plasma test detects Abeta(1–42) and Abeta(1–40) in Alzheimer’s disease
- Elisabeth H. Thijssen
- , Inge M. W. Verberk
- & Charlotte E. Teunissen
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| Open AccessElucidating direct kinase targets of compound Danshen dropping pills employing archived data and prediction models
- Tongxing Wang
- , Lu Liang
- & Yunhui Hu
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| Open AccessA survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
- , Nicolas Joly
- & Peter J. Roy
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| Open AccessCompetitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena
- Sandra Lage
- , Hanna Mazur-Marzec
- & Elena Gorokhova
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| Open AccessUltrasensitive nucleic acid detection based on phosphorothioated hairpin-assisted isothermal amplification
- Yujin Jung
- , Jayeon Song
- & Hyun Gyu Park