Structure determination articles within Nature

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  • Article
    | Open Access

    Structure of human nuclear pore complex in its cellular environment reveals a substantially dilated central channel and shows that its nucleoplasmic and cytoplasmic rings restrict channel dimensions and create membrane asymmetry at the inner ring.

    • Anthony P. Schuller
    • , Matthias Wojtynek
    •  & Thomas U. Schwartz

  • Article |

    Structural studies of the dimerization quality control E3 ubiquitin ligase SCF–FBXL17 indicate that its selectivity for aberrant complex formation is based on recognizing both shape and complementarity of interacting domains.

    • Elijah L. Mena
    • , Predrag Jevtić
    •  & Michael Rape

  • Article |

    The structure of the yeast nuclear pore complex, determined at sub-nanometre precision using an integrative approach that combines a wide range of data, reveals details of its architecture, transport mechanism and evolutionary origins.

    • Seung Joong Kim
    • , Javier Fernandez-Martinez
    •  & Michael P. Rout

  • Article |

    The structure of the bacterial toxin BinAB, which is used to combat mosquito-borne diseases, reveals pH-sensitive switches and carbohydrate-binding modules that may contribute to the larvicidal function of the toxin.

    • Jacques-Philippe Colletier
    • , Michael R. Sawaya
    •  & David S. Eisenberg

  • Letter |

    The crystal structure of mouse SCD1 bound to fatty acid stearoyl-CoA is solved at 2.6 Å resolution; the structure reveals a novel geometry for the dimetal centre, and the acyl chain of the bound fatty acid is shown to be shielded and shaped to a particular conformation by the enzyme, providing a structural basis for the selectivity of fatty acid metabolism.

    • Yonghong Bai
    • , Jason G. McCoy
    •  & Ming Zhou

  • Letter |

    A method, termed hiCLIP, has been developed to determine the RNA duplexes bound by RNA-binding proteins, revealing an unforeseen prevalence of long-range duplexes in 3′ untranslated regions (UTRs), and a decreased incidence of SNPs in duplex-forming regions; the results also show that RNA structure is able to regulate gene expression.

    • Yoichiro Sugimoto
    • , Alessandra Vigilante
    •  & Jernej Ule

  • Letter |

    The radiation-damage-free structure of the photosystem II membrane protein complex, which oxidizes water into dioxygen in an oxygen evolving complex, has been determined by an X-ray free electron laser at a resolution of 1.95 Å; one of the substrate oxygen atoms in this reaction is now identified.

    • Michihiro Suga
    • , Fusamichi Akita
    •  & Jian-Ren Shen

  • Obituary |

    Crystallographer who pioneered methods of X-ray imaging and modern computing.

    • Janos Kirz
    •  & Jianwei Miao

  • Letter |

    Propionyl-coenzyme A carboxylase (PCC) is a biotin-dependent enzyme that is essential for the catabolism of several amino acids, cholesterol and some fatty acids. Here, the crystal structure of a bacterial PCC is presented, along with a cryo-electron microscopy reconstruction showing a similar structure for human PCC. The structural information establishes a molecular basis for understanding the known disease-causing mutations in PCC, and is relevant to the holoenzymes of other biotin-dependent carboxylases.

    • Christine S. Huang
    • , Kianoush Sadre-Bazzaz
    •  & Liang Tong

  • Letter |

    An imaging technique that could identify all the individual atoms, including defects, in a material would be a useful tool. Here an electron-microscopy approach to the problem, based on annular dark-field imaging, is described. A monolayer of boron nitride was studied, and three types of atomic substitution were identified. Careful analysis of the data enabled the construction of a detailed map of the atomic structure.

    • Ondrej L. Krivanek
    • , Matthew F. Chisholm
    •  & Stephen J. Pennycook

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