Stem cells in the nervous system

Stem cells in the nervous system are self-renewing cells that have the capacity to produce all, or a restricted set of, the neural cell types (neurons and glia) in the nervous system. Stem cells can be found in the developing and adult nervous system.

Latest Research and Reviews

  • Research |

    Sequencing of total and ribosome-associated mRNAs enables identification of specific mRNAs that are differentially translationally regulated along the neuronal stem cell lineage, independently of their availability.

    • Avni Baser
    • , Maxim Skabkin
    • , Susanne Kleber
    • , Yonglong Dang
    • , Gülce S. Gülcüler Balta
    • , Georgios Kalamakis
    • , Manuel Göpferich
    • , Damian Carvajal Ibañez
    • , Roman Schefzik
    • , Alejandro Santos Lopez
    • , Enric Llorens Bobadilla
    • , Carsten Schultz
    • , Bernd Fischer
    •  & Ana Martin-Villalba
    Nature 566, 100-104
  • Research |

    There are no new oligodendrocytes in potentially remyelinated multiple sclerosis shadow plaques, although oligodendrocyte generation is increased in the normal appearing white matter of patients with aggressive disease, informing the development of new therapies.

    • Maggie S. Y. Yeung
    • , Mehdi Djelloul
    • , Embla Steiner
    • , Samuel Bernard
    • , Mehran Salehpour
    • , Göran Possnert
    • , Lou Brundin
    •  & Jonas Frisén
    Nature, 1-5
  • Protocols |

    This protocol describes how to inject therapeutic cells, viruses, or other macromolecular products into the mouse or rat lumbar ventral cord, modeling the routes used for administration of therapies currently in use in human clinical trials.

    • Kevin S. Chen
    • , Lisa M. McGinley
    • , Osama N. Kashlan
    • , John M. Hayes
    • , Elizabeth S. Bruno
    • , Josh S. Chang
    • , Faye E. Mendelson
    • , Maegan A. Tabbey
    • , Karl Johe
    • , Stacey A. Sakowski
    •  & Eva L. Feldman
    Nature Protocols 14, 331-349
  • Research |

    A protocol adapted to xeno- and feeder-free conditions is shown to generate reliable and consistent cortical brain organoids across differentiations and source stem cell lines, making it suitable for disease modeling and other applications.

    • Se-Jin Yoon
    • , Lubayna S. Elahi
    • , Anca M. Pașca
    • , Rebecca M. Marton
    • , Aaron Gordon
    • , Omer Revah
    • , Yuki Miura
    • , Elisabeth M. Walczak
    • , Gwendolyn M. Holdgate
    • , H. Christina Fan
    • , John R. Huguenard
    • , Daniel H. Geschwind
    •  & Sergiu P. Pașca
    Nature Methods 16, 75-78

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