Skeleton articles within Nature Reviews Rheumatology

Featured

• Review Article | 24 May 2023

  Bone marrow lesions: plugging the holes in our knowledge using animal models

  Bone marrow lesions (BMLs) are considered possible biomarkers and therapeutic targets in osteoarthritis, but human studies of BMLs have important limitations. In this Review, the authors explore the utility and potential of animal models in BML research.

  • Rebecca T. Hansen
  • , Chantal Chenu
  •  & Andrew A. Pitsillides

• Research Highlight | 31 January 2022

  Kindlin-2 reduces IVD inflammation

  Preclinical research suggests the focal adhesion protein kindlin-2 protects against intervertebral disc degeneration.

  • Michael Attwaters

• In Brief | 21 July 2015

  Golimumab gets the green light in GO-AHEAD

• Review Article | 16 June 2015

  The role of hedgehog signalling in skeletal health and disease

  This article discusses the role of hedgehog signalling in bone health and disease. Targeting this pathway could retard the rate of degeneration in osteoarthritis, promote bone repair, and inhibit cartilage tumour viability. As such, hedgehog signalling could be manipulated to safeguard skeletal health.

  • Benjamin A. Alman

• Review Article | 21 April 2015

  A look behind the scenes: the risk and pathogenesis of primary osteoporosis

  This article discusses the many heritable and nonheritable factors contributing to primary osteoporosis, focusing on osteogenesis imperfecta, juvenile osteoporosis and other monogenic disorders associated with increased bone fragility. Understanding these conditions not only illuminates the pathogenesis of osteoporosis, but could also lead to the discovery of new therapeutic targets.

  • Gretl Hendrickx
  • , Eveline Boudin
  •  & Wim Van Hul