In Brief |
Featured
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Method to Watch |
CRISPR targets RNA
Having revolutionized DNA editing, CRISPR turns to RNA.
- Nicole Rusk
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Research Highlights |
Of TRIBE and RNA tagging
Genetic approaches profile RNA–protein interactions.
- Nicole Rusk
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Brief Communication |
Identifying RNA editing sites using RNA sequencing data alone
Highly accurate and sensitive predictions of RNA editing sites can be obtained using RNA sequencing data from multiple individuals or species, without relying on matched genomic DNA sequence. Reanalyzing existing RNA sequencing data in this way greatly expands the catalog of human protein recoding events.
- Gokul Ramaswami
- , Rui Zhang
- & Jin Billy Li
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Brief Communication |
Accurate identification of human Alu and non-Alu RNA editing sites
A computational framework is reported for the accurate and sensitive identification of RNA editing sites from whole-genome DNA and RNA sequences from the same individual.
- Gokul Ramaswami
- , Wei Lin
- & Jin Billy Li
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News & Views |
Making sense out of nonsense to visualize editing in the fly nervous system
In vivo methods to capture processing events such as RNA editing in specific cell types are sparse. Researchers have now developed a method to visualize adenosine-to-inosine editing activity in individual fruit fly neurons using a reverse-engineered fluorescent reporter.
- Chammiran Daniel
- & Marie Öhman
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Article |
Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system
Adenosine-to-inosine RNA editing modifies expressed sequences and enhances functional protein diversity. The authors report an in vivo fluorescent reporter that provides a readout of adenosine deaminase RNA-editing activity in Drosophila melanogaster neurons, showing evidence of inter-individual variability in editing activity.
- James E C Jepson
- , Yiannis A Savva
- & Robert A Reenan
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Research Highlights |
Searching for mismatches in a vast genomic landscape
Raw data of millions of sequences used to assemble the reference genomes of ten organisms are analyzed in search of mismatches indicative of editing events. Findings include candidate sites for in vivo DNA and RNA editing, and a common sequencing error.
- Erika Pastrana
