Review Article |
Featured
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Review Article |
The regulation of endocrine-disrupting chemicals to minimize their impact on health
Endocrine-disrupting chemicals (EDCs) contribute to human disease, disability and economic damage. This Review outlines a set of evidence-based policy actions to manage, minimize or eliminate the use of EDCs, alongside a number of specific challenges and potential recommendations.
- Carol Duh-Leong
- , Maricel V. Maffini
- & Leonardo Trasande
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News & Views |
Urban built environments: interventions for reducing cardiometabolic risks
Cities with varied development types and green space are known to be protective for cardiometabolic health, while those with higher traffic-related pollution, access to calorie-dense food and poorer perception of safety are detrimental. These factors should be considered when planning urban developments in lower-income and middle-income countries to reduce cardiometabolic disease burden.
- Chinmoy Sarkar
- & Ka Yan Lai
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Research Highlight |
Functional HNF1A variants linked with T2DM risk in European-ancestry populations
- Katrin Legg
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Review Article |
The multiple roles of life stress in metabolic disorders
Life stress is known to affect the development and progression of metabolic diseases. This Review discusses the pathophysiological mechanisms underlying the association between stress and metabolic disease, and evaluates the epidemiological evidence for the influence of stress on metabolic disease.
- Mika Kivimäki
- , Alessandro Bartolomucci
- & Ichiro Kawachi
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Review Article |
A global view of hypertensive disorders and diabetes mellitus during pregnancy
Two maternal cardiometabolic disorders, hypertensive disorders in pregnancy (HDP) and gestational diabetes mellitus (GDM), affect many pregnant individuals worldwide. This Review discusses the global disease burden and risk factors for HDP and GDM and discusses public health interventions that might help reduce the associated mortality and morbidity.
- Li Jiang
- , Kun Tang
- & Zulfiqar A. Bhutta
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Correspondence |
Lactate as a major myokine and exerkine
- George A. Brooks
- , Adam D. Osmond
- & Robert G. Leija
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News & Views |
The emerging role of lipidomics in prediction of diseases
A recent paper published in PLoS Biology reported the application of lipidomics in predicting the incidence of type 2 diabetes mellitus and cardiovascular diseases in a population cohort. The study demonstrates the role of lipidomics in prediction of diseases and translational research, which could herald the beginning of an era of quantitative lipidomics.
- Xianlin Han
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Correspondence |
Reply to ‘Paracetamol use in pregnancy — neglecting context promotes misinterpretation’
- Ann Z. Bauer
- , Shanna H. Swan
- & David M. Kristensen
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Review Article |
The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases
Evidence from cohort studies and clinical trials supports an aetiological role of sugar-sweetened beverage (SSB) intake in the development of obesity and related chronic diseases. This Review provides an up-to-date view, considering the evidence, potential mechanisms and policy actions to reduce the global intake of SSBs.
- Vasanti S. Malik
- & Frank B. Hu
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Correspondence |
Reply to ‘Paracetamol use in pregnancy — caution over causal inference from available data’; ‘Handle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy’
- Ann Z. Bauer
- , Shanna H. Swan
- & David M. Kristensen
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Correspondence |
Paracetamol use in pregnancy — caution over causal inference from available data
- Sura Alwan
- , Elizabeth A. Conover
- & Katherine L. Wisner
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Editorial |
Caution needed: paracetamol use in pregnancy
A new Consensus Statement calls for precautionary action around the use of paracetamol in pregnancy, through focused research efforts and by increasing awareness.
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Review Article |
Improving clinical outcomes through attention to sex and hormones in research
Sex differences can have important implications in research and medical care. This Review will outline our understanding on sex differences, and will offer strategies that, if implemented, will provide information with which to personalize and improve health care for all people.
- Michelle M. Mielke
- & Virginia M. Miller
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News & Views |
Severe COVID-19 outcomes — the role of physical activity
COVID-19 has been described as a syndemic of COVID-19 and chronic diseases. Obesity has been identified as a contributing factor to morbidity and mortality associated with COVID-19; however, sedentary behaviours and lack of physical activity should also be targeted by health authorities to reduce the risk of severe COVID-19 outcomes.
- Jean-Pierre Després
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News & Views |
Adiposity measures and mortality in an Asian population
U-shaped or J-shaped relationships have been demonstrated between BMI and all-cause or cardiovascular mortality. Now, a study has demonstrated the correlation of increased waist circumference, high adipose tissue mass and low adipose tissue-free mass with all-cause and cardiovascular mortality in an Asian population.
- Shizuya Yamashita
- & Yuji Matsuzawa
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Review Article |
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver
This Review provides insight into sexual dimorphism in adipose tissue distribution and substrate metabolism in adipose tissue, skeletal muscle and liver, as well as the underlying mechanisms. The effects of these sex differences on cardiometabolic health are outlined and the potential for developing sex-specific prevention and treatment strategies is discussed.
- Gijs H. Goossens
- , Johan W. E. Jocken
- & Ellen E. Blaak
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Perspective |
Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer
Disruption of the circadian system can alter microbiome communities and can perturb host metabolism leading to the metabolic syndrome. This Perspective discusses the role of intestinal microbiota in mediating the effects circadian dysrhythmia on human health.
- Faraz Bishehsari
- , Robin M. Voigt
- & Ali Keshavarzian
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Comment |
Managing fragility fractures during the COVID-19 pandemic
The COVID-19 pandemic has broad implications for the care of patients with bone fragility. A dramatic surge in fractures and related mortality is expected in the next few months. We pledge to intensify the current efforts to improve the management of bone health, and to prioritize fragility fracture care and prevention.
- Nicola Napoli
- , Ann L. Elderkin
- & Sundeep Khosla
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Research Highlight |
Genetic analysis reveals role of testosterone levels in human disease
- Claire Greenhill
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Correspondence |
Chinese Famine and the diabetes mellitus epidemic
- Paul Zimmet
- , Zumin Shi
- & Linong Ji
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Correspondence |
Reply to ‘Chinese famine and the diabetes mellitus epidemic’
- Chihua Li
- , Elmar W. Tobi
- & L. H. Lumey
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Correspondence |
Early-life exposure to the Chinese Famine and subsequent T2DM
- Zhiyong Zou
- , Changwei Li
- & George C. Patton
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Correspondence |
Reply to ‘Early-life exposure to the Chinese Famine and subsequent T2DM’
- Chihua Li
- , Elmar W. Tobi
- & L. H. Lumey
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News & Views |
Sex-dependent link between circadian misalignment and adiposity
A cross-sectional study shows that proxies of circadian misalignment, such as late chronotype and social jet lag, are associated with increased adiposity in adolescent girls but not adolescent boys, highlighting a potential sex-specific effect of circadian misalignment. Interventions targeting sleep timing should be considered in the prevention of adolescent obesity.
- Jingyi Qian
- & Frank A. J. L. Scheer
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Consensus Statement
| Open Access
Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
In this Expert Consensus Statement, the authors define 10 key characteristics (KCs) for endocrine-disrupting chemicals. They further describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs.
- Michele A. La Merrill
- , Laura N. Vandenberg
- & R. Thomas Zoeller
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Comment |
Identifying the waist circumference of risk in people of African descent
The relationship between type 2 diabetes mellitus (T2DM), insulin resistance and central obesity is not uniformly applicable to populations worldwide. In this Comment, we discuss the challenge of establishing waist circumference thresholds to predict T2DM in Africa.
- Anne E. Sumner
- & Mohammad Hadi Bagheri
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News & Views |
Topical glucocorticoids and risk of type 2 diabetes mellitus
A positive association between topical corticosteroid use and risk of type 2 diabetes mellitus has been reported in a large European population-based study. However, the increase in risk is small and should not influence the prescribing of topical corticosteroids when clinically indicated.
- E. C. Johns
- & R. M. Reynolds
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Review Article |
Improving pregnancy outcomes in women with diabetes mellitus: modern management
Women with pre-existing diabetes mellitus are at increased risk of complications during pregnancy. This Review outlines the latest management strategies that have been designed to reduce this risk, including diet and pharmacotherapy options.
- Lene Ringholm
- , Peter Damm
- & Elisabeth R. Mathiesen
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Perspective |
Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA
The aim of the Consortium Linking Academic and Regulatory Insights on Toxicity of BPA (CLARITY–BPA) was to provide a definitive evaluation of bisphenol A (BPA). In this Perspectives, the authors summarize the goals, design and problems of CLARITY–BPA.
- Laura N. Vandenberg
- , Patricia A. Hunt
- & Andrea C. Gore
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Year in Review |
The arrival of circadian medicine
Circadian rhythm research is beginning to show how rhythms sustain health. Genome-wide transcriptome, metabolome and proteome studies have improved our understanding of circadian regulation. This knowledge is leveraged for behavioural interventions that optimize daily rhythms, the timing of drug delivery and the targeting of clock components to prevent or treat chronic diseases.
- Satchidananda Panda
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News & Views |
The wave of sweetness and obesity continues
Evidence for the predictive value of IADPSG/WHO2013 diagnostic gestational diabetes mellitus criteria for long-term maternal and offspring outcomes is missing. Recently, William L Lowe Jr and colleagues report a high risk of maternal glycaemic disorders and childhood adiposity 10 to 14 years after untreated gestational diabetes mellitus in the HAPO Follow-up Study.
- Alexandra Kautzky-Willer
- & Jürgen Harreiter
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Review Article |
Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine
This Review discusses the role of the Chinese Famine in the current epidemic of type 2 diabetes mellitus in China and highlights lessons to be learned.
- Paul Zimmet
- , Zumin Shi
- & Linong Ji
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News & Views |
IFNγ — link between infections and cardiometabolic risk?
Viral infections induce muscle insulin resistance in mice through the stimulation of IFNγ. This results in increased insulin levels, which promote antiviral CD8+ T cell activation. In obese mice, insulin resistance triggered by IFNγ also leads to deterioration of glycaemic control. These findings highlight the intricate link between the immune system and metabolic regulation.
- Christian Herder
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News & Views |
Exercise as medicine for survivors of paediatric cancer
Evidence suggests that physical activity is beneficial for patients with and survivors of cancer. A recent study found that vigorous exercise was associated with reduced mortality in paediatric cancer survivors. Here we discuss these findings in the context of potential mechanisms mediating some of the health effects of exercise in cancer.
- Marit Hjorth
- & Mark A. Febbraio
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News & Views |
Breast milk, formula, the microbiome and overweight
Jessica D. Forbes and colleagues found that infants who received formula early in life were more likely to be overweight at 1 year of age than those exclusively breastfed. Formula feeding was associated with altered intestinal microbiome characteristics at 3 months. These findings link early-life formula feeding and an altered microbiome with subsequent overweight.
- Elisabetta Mueller
- & Martin Blaser
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News & Views |
Amino acids — lifesaver or killer in patients with diabetes?
Distinct circulating amino acids are suggested to modulate the risk of complications and mortality related to diabetes mellitus. These findings pave the way for future basic and clinical studies to gain new insights into the pathogenesis and treatment of diabetes mellitus.
- Sabine Kahl
- & Michael Roden
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News & Views |
The search for predictive metabolic biomarkers for incident T2DM
A recent metabolomics study of plasma samples from normoglycaemic individuals has identified new predictive biomarkers for type 2 diabetes mellitus. The biomarkers described by the authors demonstrate a potential causal connection between changes in glycine and phenylalanine and incident diabetes mellitus.
- Ewan Pearson
- & Jerzy Adamski
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News & Views |
Inflated pathogenic variant profiles in the ClinVar database
A recent unbiased study found inflation of the genetic risk of endocrine tumour syndromes in the genotype–phenotype database ClinVar. Here, we discuss the interesting findings and point to potential limitations of this work in light of the recently established consensus statement of the Pheochromocytomas and Paragangliomas (NGSnPPGL) Study Group.
- Rodrigo A. Toledo
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News & Views |
Antithyroid drugs and congenital malformations
A new study showed that propylthiouracil and methimazole use during pregnancy was associated with increased risk of congenital malformations. Intriguingly, the authors identified dose-dependent effects for methimazole but not propylthiouracil, whereas the recommended switch from methimazole to propylthiouracil during early pregnancy did not reduce the risk of congenital malformations.
- Tim I. M. Korevaar
- & Robin P. Peeters
Sarcopenic obesity in older adults: a clinical overview
Scrutinizing the effect of BPS on adipose tissue
Fructose and metabolic health
Maternal obesity disrupts hypothalamic development
Maternal paraben exposure and childhood weight gain
Transgenerational effects of polycystic ovary syndrome identified
Sugar-sweetened beverages — another study recommends replacement
The endocannabinoid system in human testes