A recent metabolomics study of plasma samples from normoglycaemic individuals has identified new predictive biomarkers for type 2 diabetes mellitus. The biomarkers described by the authors demonstrate a potential causal connection between changes in glycine and phenylalanine and incident diabetes mellitus.
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Acknowledgements
The authors’ work was supported, in part, by Innovative Medicines Initiative Joint Undertaking under grant agreement number 115317 (DIRECT), European Institute of Innovation & Technology (EIT) Health Innovation Projects grant DeTecT2D (18428) and the German Federal Ministry of Education and Research (BMBF) to the German Center Diabetes Research (DZD e.V.) grant that was awarded to J.A. E.R.P. holds a Wellcome trust New investigator award (102820/Z/13/Z).
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Pearson, E., Adamski, J. The search for predictive metabolic biomarkers for incident T2DM. Nat Rev Endocrinol 14, 444–446 (2018). https://doi.org/10.1038/s41574-018-0045-x
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DOI: https://doi.org/10.1038/s41574-018-0045-x