Phospholipids articles within Nature Chemistry

Featured

• Article | 22 May 2023

  Activity-based directed evolution of a membrane editor in mammalian cells

  Cellular membranes contain numerous lipids, and efforts to understand the biological functions of individual lipids demand approaches for controlled modulation of membrane composition in situ. Now, click chemistry-based directed evolution of a microbial phospholipase within mammalian cells affords an editor for optogenetic, targeted modification of phospholipids in cell membranes.

  • Reika Tei
  • , Saket R. Bagde
  •  & Jeremy M. Baskin

• Article | 13 June 2016

  Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes

  Cell-sized asymmetric giant lipid vesicles containing a very small amount of organic solvent have now been formed via inhomogeneous break-up of a lipid microtube that was generated by applying a jet flow to an asymmetric planar lipid bilayer. The asymmetric giant vesicles were used to investigate the dynamic responses of lipid molecules and the effect of asymmetry on biochemical reactions.

  • Koki Kamiya
  • , Ryuji Kawano
  •  & Shoji Takeuchi