Phase-contrast microscopy articles within Nature Communications

Featured

• Article
  28 November 2023 | Open Access

  Label-free identification of protein aggregates using deep learning

  The authors use deep learning to detect and segment unlabeled and unaltered protein aggregates in living cells from transmitted-light images. The method provides a way to quantitatively study protein aggregation dynamics in a simple, fast and accurate way.

  • Khalid A. Ibrahim
  • , Kristin S. Grußmayer
  •  & Aleksandra Radenovic

• Article
  06 September 2022 | Open Access

  Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics

  The authors introduce differentially enhanced compressed ultrafast photography, a phase imaging platform that combines high speed and sensitivity. They visualise propagation of passive current flows along myelinated axons, and electromagnetic pulses in lithium niobate.

  • Yide Zhang
  • , Binglin Shen
  •  & Lihong V. Wang

• Article
  16 October 2019 | Open Access

  Epi-illumination gradient light interference microscopy for imaging opaque structures

  Quantitative phase imaging techniques have been limited by multiple scattering of light or its use in transmission mode. Here, the authors show a gradient light interference microscopy method in a reflection geometry which allows for label-free phase imaging of bulk and opaque samples.

  • Mikhail E. Kandel
  • , Chenfei Hu
  •  & Gabriel Popescu

• Article
  09 October 2017 | Open Access

  A three-dimensional view of structural changes caused by deactivation of fluid catalytic cracking catalysts

  Catalyst deactivation in fluid catalytic cracking processes is unavoidably associated with structural changes. Here, the authors visualize the deactivation of zeolite catalysts by ptychography and other imaging techniques, showing pronounced amorphization of the outer layer of the catalyst particles.

  • J. Ihli
  • , R. R. Jacob
  •  & J. A. van Bokhoven

• Article
  08 August 2017 | Open Access

  Gradient light interference microscopy for 3D imaging of unlabeled specimens

  Challenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.

  • Tan H. Nguyen
  • , Mikhail E. Kandel
  •  & Gabriel Popescu

• Article
  27 September 2016 | Open Access

  Multi-pass microscopy

  Low-damage and high-precision imaging can be achieved by passing the same probe photons through the specimen more than once, and this has been previously achieved in double-pass transmission microscopy. Here, the authors generalize this idea to full-field multi-pass microscopy using a self-imaging cavity.

  • Thomas Juffmann
  • , Brannon B. Klopfer
  •  & Mark A. Kasevich

• Article
  05 November 2013 | Open Access

  Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings

  Phase-contrast imaging has become popular for medical diagnostic purposes because of the ability to see transparent structures at relatively small radiation energy dosed to samples. Wenet al.further develop this technique using nanometric phase gratings to achieve subnanoradian sensitivity.

  • Han Wen
  • , Andrew A. Gomella
  •  & Douglas E. Wolfe