Pharmacodynamics articles within Nature Chemistry

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• Article | 27 November 2011

  Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity

  The self-assembly of monometallic moieties with organic ligands has proved to be a highly versatile approach for preparing a range of metal–ligand assemblies that are helical, optically pure and stable in aqueous solutions. One such iron(II) ‘flexicate’ system exhibits significant interactions with DNA, as well as promising antimicrobial activity properties.

  • Suzanne E. Howson
  • , Albert Bolhuis
  •  & Peter Scott

• Article | 21 August 2011

  The transcription factor FOXM1 is a cellular target of the natural product thiostrepton

  The natural product thiostrepton is known to have anticancer properties but its mechanism of action is not known. Here, it is shown that thiostrepton binds to the protein FOXM1, preventing its interaction with several gene promoters and inhibits their expression. This illustrates the druggability of transcription factors, and provides a molecular basis for targeting FOXM1.

  • Nagaratna S. Hegde
  • , Deborah A. Sanders
  •  & Shankar Balasubramanian