Pattern recognition receptors

Pattern recognition receptors (PRRs) are expressed by cells in the body in order to sense molecules that are associated with infection or tissue damage. They are important for activating the immune system.

Latest Research and Reviews

  • Research |

    The cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK1 requires oligomerization of both proteins.

    • Conggang Zhang
    • , Guijun Shang
    • , Xiang Gui
    • , Xuewu Zhang
    • , Xiao-chen Bai
    •  & Zhijian J. Chen
    Nature, 1-5
  • Research | | open

    Amphihelical antimicrobial peptides (AMPs) are bactericidal host defense factors, but their function as immunomodulators is emerging. Here the authors show that several AMPs organize DNA into periodic nanocrystals by self-assembling into superhelical protofibril scaffolds, which potentiates DNA sensing by TLR9.

    • Ernest Y. Lee
    • , Changsheng Zhang
    • , Jeremy Di Domizio
    • , Fan Jin
    • , Will Connell
    • , Mandy Hung
    • , Nicolas Malkoff
    • , Veronica Veksler
    • , Michel Gilliet
    • , Pengyu Ren
    •  & Gerard C. L. Wong
  • Research |

    A bacterial family of cGAS/DncV-like nucleotidyltransferases synthesizes a diverse range of cyclic dinucleotide and trinucleotide compounds that are likely to modulate the interaction of both pathogens and commensal microbiota with their animal and plant hosts.

    • Aaron T. Whiteley
    • , James B. Eaglesham
    • , Carina C. de Oliveira Mann
    • , Benjamin R. Morehouse
    • , Brianna Lowey
    • , Eric A. Nieminen
    • , Olga Danilchanka
    • , David S. King
    • , Amy S. Y. Lee
    • , John J. Mekalanos
    •  & Philip J. Kranzusch
    Nature 567, 194-199

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