Next-generation sequencing articles within Nature

Featured

• Letter | 24 April 2013

  Extensive transcriptional heterogeneity revealed by isoform profiling

  Variation among RNA transcript isoforms can be generated from alternative start and polyadenylation sites, and results in RNAs and proteins with different properties being generated from the same genomic sequence; here a new method termed transcript isoform sequencing is described in yeast, and the method allows a fuller exploration of transcriptome diversity across the compact yeast genome.

  • Vicent Pelechano
  • , Wu Wei
  •  & Lars M. Steinmetz

• Letter | 07 April 2013

  Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

  A proof of principle study shows that by exome sequencing of cell-free circulating DNA from cancer patient plasma samples, the genomic evolution of metastatic cancers and the acquisition of resistance in response to therapy can be tracked over time.

  • Muhammed Murtaza
  • , Sarah-Jane Dawson
  •  & Nitzan Rosenfeld

• Letter | 16 January 2013

  Discrete genetic modules are responsible for complex burrow evolution in Peromyscus mice

  The complex burrows created by oldfield mice are shown to be governed by genetic modules that each control an aspect of burrow size or shape.

  • Jesse N. Weber
  • , Brant K. Peterson
  •  & Hopi E. Hoekstra

• News | 25 September 2012

  China buys US sequencing firm

  BGI’s rescue of Complete Genomics will keep a valued technology afloat.

  • Monya Baker

• Review Article | 12 September 2012

  Genomic approaches to studying the human microbiota

  • George M. Weinstock

• News | 23 July 2012

  Contest to sequence centenarians kicks off

  First entrant pins hopes on semiconductor technology.

  • Monya Baker

• Research Highlights | 30 May 2012

  Sequencing spots tumour cells

• News | 25 April 2012

  RNA studies under fire

  High-profile results challenged over statistical analysis of sequence data.

  • Erika Check Hayden

• News Q&A | 22 April 2012

  Next-generation genome sequencers compared

  Three main platforms compete in head-to-head battle.

  • Erika Check Hayden

• News | 12 April 2012

  Screen uncovers hidden ingredients of Chinese medicine

  Genetic audit reveals that some traditional remedies contain endangered animals and toxic plants.

  • Ewen Callaway

• News | 02 February 2012

  Norway to bring cancer-gene tests to the clinic

  A pilot programme will use latest tumour-sequencing techniques to help guide cancer care.

  • Ewen Callaway

• Article | 21 September 2011

  Deep sequencing reveals 50 novel genes for recessive cognitive disorders

  • Hossein Najmabadi
  • , Hao Hu
  •  & H. Hilger Ropers

• News | 18 February 2010

  Personalized biomarkers monitor cancer

  Pilot study harnesses sequencing power to track tumours.

  • Heidi Ledford

• Authors | 13 January 2010

  Michael Stratton & Peter Campbell

  Genome sequences reveal timeline of cancer development.