Molecular medicine articles within Nature Reviews Cardiology

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  • Review Article |

    The benefits of oxygen therapy for the treatment of cardiovascular disease are unclear, and findings from preclinical studies have suggested potential adverse effects associated with its excessive use. In this Review, Eltzschig and colleagues provide an overview of studies on oxygen therapy for various cardiovascular conditions and describe alternative therapeutic strategies that target oxygen-sensing pathways.

    • Yafen Liang
    • , Wei Ruan
    •  & Holger K. Eltzschig

  • Review Article |

    In this Review, Santovito and Weber discuss the functional relevance of non-canonical features of microRNAs for cardiovascular homeostasis and pathophysiology, describing the role of atypical microRNA biogenesis and localization, RISC heterogeneity, and non-conventional regulatory functions, including direct protein interactions and transcriptional regulation in the nucleus and in mitochondria.

    • Donato Santovito
    •  & Christian Weber

  • Comment |

    Genomic data are increasingly being integrated into health care. We propose an outline for structured training in cardiovascular genomics, recognizing the growing need for a cardiovascular genomics subspecialty and cardiovascular subspecialists who incorporate genomics advances to optimize the management of heritable cardiovascular diseases.

    • Maya S. Safarova
    • , Michael J. Ackerman
    •  & Iftikhar J. Kullo

  • Review Article |

    In this Review, Weldy and Ashley summarize the biology of heart failure (HF), the mechanisms of action of HF drugs, and both the Mendelian genetics of cardiomyopathies and the complex genetics of HF. Finally, they present a roadmap for the future of precision medicine in HF.

    • Chad S. Weldy
    •  & Euan A. Ashley

  • News & Views |

    Sequencing studies demonstrate a strong clinical association between clonal haematopoiesis driven by acquired mutations and atherosclerotic disease. Previous research supports the idea that this association reflects a direct contribution of some clonal haematopoiesis-related mutations to atherosclerosis. Now, mathematical modelling suggests that atherosclerosis could instead accelerate clonal haematopoiesis.

    • Fátima Sánchez-Cabo
    •  & José J. Fuster

  • Review Article |

    The development of the coronary vasculature involves numerous cellular sources and a multitude of distinct processes. In this Review, Smart and colleagues describe the latest insights into the mechanisms involved in coronary vessel formation during development and disease, which might contribute to the identification of therapeutic targets for the promotion of neovascularization after myocardial infarction.

    • Irina-Elena Lupu
    • , Sarah De Val
    •  & Nicola Smart

  • Review Article |

    Dysregulation of intracellular Ca2+ handling in cardiomyocytes occurs in heart failure and atrial fibrillation. In this Review, Marks and colleagues focus on diastolic Ca2+ leak from the sarcoplasmic reticulum via RYR2 as a feature and potential therapeutic target in both heart failure and atrial fibrillation.

    • Haikel Dridi
    • , Alexander Kushnir
    •  & Andrew R. Marks

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