Featured
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Obituary |
Judith Campisi (1948–2024), cell biologist who explored how cells age
Researcher who established the role of cellular senescence in cancer and ageing.
- Jan Vijg
- & Jan Hoeijmakers
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Article |
Monolithic silicon for high spatiotemporal translational photostimulation
A silicon-based electrode system is described that allows tunable spatiotemporal photostimulation of cardiac systems, with the optoelectronic capabilities of these devices being demonstrated in mouse, rat and pig heart models.
- Pengju Li
- , Jing Zhang
- & Bozhi Tian
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Article
| Open AccessPrevalence of persistent SARS-CoV-2 in a large community surveillance study
Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.
- Mahan Ghafari
- , Matthew Hall
- & Katrina Lythgoe
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News Feature |
Mind-reading devices are revealing the brain’s secrets
Implants and other technologies that decode neural activity can restore people’s abilities to move and speak — and help researchers to understand how the brain works.
- Miryam Naddaf
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News |
Move over, CRISPR: RNA-editing therapies pick up steam
Two RNA-editing therapies for genetic diseases have in the past few months gained approval for clinical trials, raising hopes for safer treatments.
- Mariana Lenharo
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News & Views |
Smoking’s lasting effect on the immune system
It emerges from a study of human cells that smoking can influence certain immune responses to the same extent as can age or genetics. Smoking can alter the immune system in ways that persist long after quitting the habit.
- Yang Luo
- & Simon Stent
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News Feature |
The future of precision cancer therapy might be to try everything
Researchers are blasting patients’ cancer cells with dozens of drugs in the hope of finding the right treatment.
- Elie Dolgin
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Career Q&A |
A researcher-exchange programme made me a better doctor at home and abroad
Caleb Skipper describes how global health collaborations bring valuable transfers of knowledge to both sides of the Atlantic.
- Christopher Bendana
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News |
Turbocharged CAR-T cells melt tumours in mice — using a trick from cancer cells
Immune cells armed with a mutation first identified in cancer cells gain potency but don’t turn cancerous themselves.
- Asher Mullard
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News |
Crackdown on skin-colour bias by fingertip oxygen sensors is coming, hints FDA
Devices can overestimate blood oxygen levels in people with dark skin, affecting medical care.
- Max Kozlov
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News |
Why autoimmune disease is more common in women: X chromosome holds clues
Rogue antibodies are drawn to the protein–RNA coating on half of the X chromosomes in an XX cell.
- Elie Dolgin
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Comment |
Forget lung, breast or prostate cancer: why tumour naming needs to change
The conventional way of classifying metastatic cancers according to their organ of origin is denying people access to drugs that could help them.
- Fabrice André
- , Elie Rassy
- & Benjamin Besse
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News Feature |
Can autoimmune diseases be cured? Scientists see hope at last
After decades of frustration and failed attempts, scientists might finally be on the cusp of developing therapies to restore immune ‘tolerance’ in conditions such as diabetes, lupus and multiple sclerosis.
- Cassandra Willyard
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News |
Fingertip oxygen sensors can fail on dark skin — now a physician is suing
A community health centre in California led by the researcher files the first lawsuit against pulse oximeter manufacturers.
- Anil Oza
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News |
Potent new pill provides COVID relief for the masses
The drug simnotrelvir shortens symptoms for those with mild infections and is sold at a lower price in China than its main rival.
- Saima Sidik
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News Q&A |
New NIH chief opens up about risky pathogens, postdoc salaries and the year ahead
Nature talks to Monica Bertagnolli about hot-button issues and her top priorities for 2024.
- Max Kozlov
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News |
Google AI has better bedside manner than human doctors — and makes better diagnoses
Researchers say their artificial-intelligence system could help to democratize medicine.
- Mariana Lenharo
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News Feature |
Antibiotic resistance is a growing threat — is climate change making it worse?
Researchers are studying how extreme weather and rising temperatures can encourage the spread of drug-resistant infections.
- Carissa Wong
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News |
Potent psychedelic drug banishes PTSD, small study finds
Military veterans with cognitive and psychological problems saw drastic improvements after a dose of ibogaine.
- Max Kozlov
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Research Highlight |
A record-setting transplant heals a baby’s broken heart
Partial-heart transplant from a living donor allows an infant's heart valves to grow as he does.
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Editorial |
A new class of antibiotics is cause for cautious celebration — but the economics must be fixed
The threat of antimicrobial resistance means that new antibiotics need to be used sparingly. Governments must support their development with a long-term funding plan.
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News Feature |
Long COVID is a double curse in low-income nations — here’s why
Not only is the prevalence of the condition poorly understood, but it’s also often ignored by physicians and the wider public.
- Heidi Ledford
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News |
Cancer-fighting CAR T cells could be made inside body with viral injection
Scientists are devising ways to edit the genomes of immune cells without having to extract them from the people being treated.
- Heidi Ledford
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News |
Scientists question cancer tests that use microscopic nematode worms
Some doctors say a troublingly high number of cancer-free people have tested positive on the tests sold by a Japanese start-up.
- David McNeill
- & Momoko Suda
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News & Views |
A next-generation inhalable dry powder COVID vaccine
Current injectable COVID-19 vaccines are unable to induce robust immunity in the mucosal tissues lining the airways. A protein-based vaccine delivered to the lungs in the form of an inhaled dry powder shows promise as a way forward.
- Zhou Xing
- & Mangalakumari Jeyanathan
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News |
Extreme morning sickness? Scientists finally pinpoint a possible cause
A protein released by fetal cells in the placenta influences the risk of experiencing severe nausea and vomiting during pregnancy.
- Carissa Wong
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News Feature |
The cancer physician who helped to deliver a life-extending treatment
Thomas Powles’s breakthrough success in treating a deadly bladder cancer could herald the next wave of powerful immunotherapeutic drugs.
- Carissa Wong
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News Feature |
Weight-loss-drug pioneer: this biochemist finally gained recognition for her work
Svetlana Mojsov led early studies of GLP-1, the hormone behind Wegovy, Ozempic and other blockbusters.
- Elie Dolgin
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Article
| Open AccessGDF15 linked to maternal risk of nausea and vomiting during pregnancy
Elevated circulating levels of GDF15 in pregnant women are associated with severe nausea and vomiting, and sensitivity to such symptoms during pregnancy is partly determined by prepregnancy levels of this hormone.
- M. Fejzo
- , N. Rocha
- & S. O’Rahilly
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News & Views |
MYC protein helps cancer to take its vitamins
Identifying nutrient dependencies of cancer cells is crucial for developing new therapies. The discovery that an aggressive type of cancer cell has a high uptake of vitamin B5 sheds light on the link between vitamin availability and tumour growth.
- Martina Wallace
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News |
‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission
Engineered immune cells, most commonly used to treat cancers, show their power against lupus and other immune disorders.
- Heidi Ledford
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Book Review |
The unsung geniuses who uncovered why we sleep and dream
Just 100 years ago, we understood astoundingly little about sleep and dreaming. A tight-knit band of researchers changed things, against sometimes considerable odds.
- Jennifer L. Martin
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News |
CRISPR 2.0: a new wave of gene editors heads for clinical trials
Landmark approval of the first CRISPR therapy paves the way for treatments based on more efficient and more precise genome editors.
- Heidi Ledford
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News & Views |
Harmful tumour–kidney interactions identified
Fatal renal dysfunction is often associated with tumour development. Fly and mouse data reveal evolutionarily conserved mechanisms that link tumours to renal failure and offer potential for future therapeutic approaches.
- Pierre Leopold
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News |
Are your organs ageing well? The blood holds clues
One organ in a person’s body can age faster than the rest — with implications for health and mortality.
- Max Kozlov
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News |
Brain implants help people to recover after severe head injury
Electrodes placed inside the brains of five people with traumatic injuries improved recipients’ performance in attention and memory tests.
- Miryam Naddaf
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Article |
Genetic risk converges on regulatory networks mediating early type 2 diabetes
Integration of multiomics data with functional analysis of pancreatic tissues from individuals with early-stage type 2 diabetes indicates that the genetic risk converges on RFX6, which regulates chromatin architecture at multiple risk loci.
- John T. Walker
- , Diane C. Saunders
- & Marcela Brissova
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Comment |
Generative AI could revolutionize health care — but not if control is ceded to big tech
Large language models such as that used by ChatGPT could soon become essential tools for diagnosing and treating patients. To protect people’s privacy and safety, medical professionals, not commercial interests, must drive their development and deployment.
- Augustin Toma
- , Senthujan Senkaiahliyan
- & Bo Wang
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News Feature |
These volunteers want to be infected with disease to aid research — will their altruism help?
An advocacy group is pushing for more ‘human challenge’ trials to spur vaccine discovery. Following COVID-19 and Zika studies, hepatitis C could be next.
- Ewen Callaway
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News & Views |
15 years after a giant leap for cancer genomics
In 2008, the first comprehensive sequence of a cancer genome was reported, ushering in a new era of molecular diagnostic, prognostic and therapeutic advances informed by an essential framework to understand cancer’s complexities.
- Sheng F. Cai
- & Ross L. Levine
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News |
ChatGPT generates fake data set to support scientific hypothesis
Researchers say that the model behind the chatbot fabricated a convincing bogus database, but a forensic examination shows it doesn’t pass for authentic.
- Miryam Naddaf
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Research Highlight |
Botox’s paralysing effects can relieve an uncontrolled head tremor
A bacterial toxin used to reduce wrinkles can also treat a common disorder in older people.
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News Explainer |
How wild monkeys ‘laundered’ for science could undermine research
Demand is fuelling an illegal trade. But smuggled monkeys carry diseases that can disrupt experiments and lead to unreliable data.
- Gemma Conroy
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Article
| Open AccessCD201+ fascia progenitors choreograph injury repair
Spatiotemporal regulation of wound healing in mice and humans occurs via retinoic acid and hypoxia signalling, which regulate the differentiation of CD201+ fibroblast progenitors into proinflammatory and myofibroblast states.
- Donovan Correa-Gallegos
- , Haifeng Ye
- & Yuval Rinkevich
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Editorial |
Brain and body are more intertwined than we knew
A host of disorders once thought to be nothing to do with the brain are, in fact, tightly coupled to nervous-system activity.
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News Feature |
The rise of brain-reading technology: what you need to know
As implanted devices and commercial headsets advance, what will the real-world impacts be?
- Liam Drew
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News |
Cancer trial results show power of weaponized antibodies
Tumour-targeting antibodies coupled with toxic chemicals are an unprecedented success in treating bladder cancer.
- Heidi Ledford
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Research Briefing |
Identification of neuronal connections between heart and brain that trigger fainting
The neural pathways involved in syncope, or fainting, are not well understood. Studies in mice have identified a defined subset of vagal sensory neurons that connect the heart and brain. Stimulation of these neurons causes reduced heart rate, blood pressure, breathing and neuronal activity in the brain, resulting in syncope.