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Harmful tumour–kidney interactions identified

Fatal renal dysfunction is often associated with tumour development. Fly and mouse data reveal evolutionarily conserved mechanisms that link tumours to renal failure and offer potential for future therapeutic approaches.
  1. Pierre Leopold

    1. Pierre Leopold is at the Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne, 75005 Paris, France.

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Kidney dysfunction or injury is commonly found in people who have cancer, contributing to illness and mortality1. Kidney disease can be the consequence of chemotherapy treatments, which in many cases induce toxicity during the elimination of these drugs in the kidney. Alternatively, the tumour can obstruct or compress the urinary tract (tissues including the prostate or bladder), which in turn can drive alterations in kidney function. An intriguing further scenario is now coming to light, with the discovery of tumour-produced molecules that modify host metabolism and organ physiology. Writing in Nature, Xu et al.2 report a study in flies and mice that provides key advances in our understanding of tumour-associated renal dysfunction.

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Nature 624, 261-262 (2023)

doi: https://doi.org/10.1038/d41586-023-03630-1

References

  1. Rosner, M. H. & Perazella, M. A. N. Engl. J. Med. 376, 1770–1781 (2017).

    Article  PubMed  Google Scholar 

  2. Xu, W., Li, G., Chen, Y., Ye, X. & Song, W. Nature 624, 425–432 (2023).

    Article  Google Scholar 

  3. Tisdale, M. J. Physiol. Rev. 89, 381–410 (2009).

    Article  PubMed  Google Scholar 

  4. Nishie, K., Nishie, T., Sato, S. & Hanaoka, M. Drug Discov. Today 28, 103689 (2023).

    Article  PubMed  Google Scholar 

  5. Setiawan, T. et al. J. Hematol. Oncol. 16, 54 (2023).

    Article  PubMed  Google Scholar 

  6. Liu, Y., Saavedra, P. & Perrimon, N. Dis. Models Mech. 15, dmm049298 (2022).

    Article  Google Scholar 

  7. Gáliková, M., Dircksen, H. & Nässel, D. R. PLoS Genet. 14, e1007618 (2018).

    Article  PubMed  Google Scholar 

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Competing Interests

The author declares no competing interests.

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