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Open Access
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Article
| Open AccessIndigenous Australian genomes show deep structure and rich novel variation
Analysis of the genomes of 159 individuals from four Indigenous communities in Australia shows a high level of genetic variation and demonstrates the need for greater representation of Indigenous Australians in reference panels and clinical databases.
- Matthew Silcocks
- , Ashley Farlow
- & Stephen Leslie
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Article
| Open AccessMexican Biobank advances population and medical genomics of diverse ancestries
Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals.
- Mashaal Sohail
- , María J. Palma-Martínez
- & Andrés Moreno-Estrada
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Perspective |
Strategic vision for improving human health at The Forefront of Genomics
In this Perspective, authors from the National Human Genome Research Institute (NHGRI) present a vision for human genomics research for the coming decade.
- Eric D. Green
- , Chris Gunter
- & Teri A. Manolio
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Article |
Genome-wide detection of tandem DNA repeats that are expanded in autism
Genome-wide analysis of tandem DNA repeats in the genomes of individuals with autism spectrum disorder and control participants reveals a strong contribution of tandem repeat expansions to the genetic aetiology and phenotypic complexity of autism spectrum disorder.
- Brett Trost
- , Worrawat Engchuan
- & Ryan K. C. Yuen
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Article
| Open AccessTranscript expression-aware annotation improves rare variant interpretation
A novel variant annotation metric that quantifies the level of expression of genetic variants across tissues is validated in the Genome Aggregation Database (gnomAD) and is shown to improve rare variant interpretation.
- Beryl B. Cummings
- , Konrad J. Karczewski
- & Daniel G. MacArthur
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Article
| Open AccessThe mutational constraint spectrum quantified from variation in 141,456 humans
A catalogue of predicted loss-of-function variants in 125,748 whole-exome and 15,708 whole-genome sequencing datasets from the Genome Aggregation Database (gnomAD) reveals the spectrum of mutational constraints that affect these human protein-coding genes.
- Konrad J. Karczewski
- , Laurent C. Francioli
- & Daniel G. MacArthur
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Article
| Open AccessThe African Genome Variation Project shapes medical genetics in Africa
The African Genome Variation Project contains the whole-genome sequences of 320 individuals and dense genotypes on 1,481 individuals from sub-Saharan Africa; it enables the design and interpretation of genomic studies, with implications for finding disease loci and clues to human origins.
- Deepti Gurdasani
- , Tommy Carstensen
- & Manjinder S. Sandhu
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Article |
The contribution of de novo coding mutations to autism spectrum disorder
Family-based exome sequencing in a large autism study has identified 27 high-confidence gene targets and accurately estimates the contribution of both de novo gene-disrupting and missense mutations to the incidence of simplex autism, with target genes in affected females overlapping those in males of lower but not higher IQ; targets also overlap known targets for intellectual disability and schizophrenia, and are enriched for chromatin modifiers, FMRP-associated genes and embryonically expressed genes.
- Ivan Iossifov
- , Brian J. O’Roak
- & Michael Wigler
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Letter |
Saturation editing of genomic regions by multiplex homology-directed repair
The authors perform saturation mutagenesis of genomic regions in their native endogenous chromosomal context by using CRISPR/Cas9 RNA-guided cleavage and multiplex homology-directed repair; its utility is demonstrated by measuring the effects of hundreds to thousands of genomic edits to BRCA1 and DBR1 on splicing and cellular fitness, respectively.
- Gregory M. Findlay
- , Evan A. Boyle
- & Jay Shendure
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Outlook |
Bioinformatics: Big data versus the big C
The torrents of data flowing out of cancer research and treatment are yielding fresh insight into the disease.
- Neil Savage
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Outlook |
Genetics: Unravelling complexity
A massive research collaboration is revealing hundreds of genes underlying schizophrenia risk, and may point the way to targeted treatments.
- Jessica Wright
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Editorial |
Share alike
To make progress in clinical genomics, institutions must work out how to pass on data.
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Editorial |
Best is yet to come
Ten years after the human genome was sequenced, its promise is still to be fulfilled.
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Perspective |
Charting a course for genomic medicine from base pairs to bedside
- Eric D. Green
- , Mark S. Guyer
- & Jane L. Peterson
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Opinion |
Multiple personal genomes await
Genomic data will soon become a commodity; the next challenge — linking human genetic variation with physiology and disease — will be as great as the one genomicists faced a decade ago, says J. Craig Venter.
- J. Craig Venter
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Opinion |
Has the revolution arrived?
Looking back over the past decade of human genomics, Francis Collins finds five key lessons for the future of personalized medicine — for technology, policy, partnerships and pharmacogenomics.
- Francis Collins