Immunology articles within Nature Chemistry

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• Review Article | 14 February 2022

  Iron–sulfur clusters as inhibitors and catalysts of viral replication

  Viruses use the cellular machinery of their host organism to reproduce. This Review discusses how [FeS] cluster-containing proteins activate, support and modulate the innate immune response to restrict viral infections as well as highlighting how some of these proteins simultaneously support the replication of viruses.

  • Kourosh Honarmand Ebrahimi
  • , Simone Ciofi-Baffoni
  •  & Fraser A. Armstrong

• Article | 22 March 2019

  Simplified immunosuppressive and neuroprotective agents based on gracilin A

  Pharmacophore-directed retrosynthesis targets a potential pharmacophore from early on in a natural product synthesis and incremental increases in the complexity of this minimal structure enable a SAR profile to develop over the course of the campaign. The method is applied to gracilin A, finding simplified derivatives displaying potent immunosuppressive effects or selective neuroprotective effects in cell-based assays.

  • Mikail E. Abbasov
  • , Rebeca Alvariño
  •  & Daniel Romo

• Article | 01 June 2014

  Development of a minimal saponin vaccine adjuvant based on QS-21

  Adjuvants are used to increase the immune response to molecular vaccines. A minimal synthetic variant of the saponin natural product QS-21 has been developed as a potent, non-toxic adjuvant, enabling dissection of structural requirements in the triterpene domain and in vivo biodistribution studies to probe mechanisms of action.

  • Alberto Fernández-Tejada
  • , Eric K. Chea
  •  & David Y. Gin

• Research Highlights | 05 February 2010

  Advancing vaccines

  Replacing readily hydrolysable ester linkages with amides in a natural adjuvant has resulted in not only more stable, but significantly more active and less toxic analogues.

  • Georgia Tsoukala