Applied immunology articles within Nature Chemistry

Featured

• Article | 01 June 2014

  Development of a minimal saponin vaccine adjuvant based on QS-21

  Adjuvants are used to increase the immune response to molecular vaccines. A minimal synthetic variant of the saponin natural product QS-21 has been developed as a potent, non-toxic adjuvant, enabling dissection of structural requirements in the triterpene domain and in vivo biodistribution studies to probe mechanisms of action.

  • Alberto Fernández-Tejada
  • , Eric K. Chea
  •  & David Y. Gin

• Research Highlights | 05 February 2010

  Advancing vaccines

  Replacing readily hydrolysable ester linkages with amides in a natural adjuvant has resulted in not only more stable, but significantly more active and less toxic analogues.

  • Georgia Tsoukala