Featured
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Article |
A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging
An erbium(III)–bacteriochlorin probe with large Stokes shift and efficient near-infrared to near-infrared energy conversion enables multiplexed imaging of deep tissues in living animals.
- Ting Wang
- , Shangfeng Wang
- & Fan Zhang
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Perspective |
Genetically encodable materials for non-invasive biological imaging
This perspective describes recent developments in genetically encoded protein contrast agents for non-invasive biological imaging, namely ultrasound, magnetic resonance and optoacoustic imaging modalities.
- Arash Farhadi
- , Felix Sigmund
- & Mikhail G. Shapiro
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Article |
Taxanes convert regions of perturbed microtubule growth into rescue sites
Anticancer drugs such as Taxol can affect microtubule dynamics and organization in cells. Direct visualization of the action of such drugs has shown that they can trigger local and cooperative changes in microtubule lattice and induce formation of stable microtubule regions that promote rescues.
- Ankit Rai
- , Tianyang Liu
- & Anna Akhmanova
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News & Views |
Gas vesicles as collapsible MRI contrast agents
Microbial gas vesicles have been developed for use as MRI contrast agents whose contrast can be inactivated by applying ultrasound waves to collapse the vesicles.
- Jeff W. M. Bulte
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Article |
Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures
Gas-filled vesicles derived from photosynthetic microbes are shown to elicit magnetic resonance imaging contrast in vitro and in vivo with the potential for acoustically modulated multiplexing and molecular sensing.
- George J. Lu
- , Arash Farhadi
- & Mikhail G. Shapiro
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Editorial |
Believing in seeing
Materials-based imaging agents are attractive candidates for a diverse range of imaging modalities and combined imaging–therapy applications, but economic implications and practical concerns remain obstacles to their clinical translation.
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News & Views |
Lighting up tumours
Detection of a wide range of tumours remains a challenge in cancer diagnostics. By exploiting changes in the tumour microenvironment, a pH-responsive polymeric nanomaterial enables ultrasensitive tumour-specific imaging in many types of cancer.
- Daishun Ling
- , Michael J. Hackett
- & Taeghwan Hyeon
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Commentary |
Tracking gene and cell fate for therapeutic gain
The preclinical intersection of molecular imaging and gene- and cell-based therapies will enable more informed and effective clinical translation. We discuss how imaging can monitor cell and gene fate and function in vivo and overcome barriers associated with these therapies.
- Nigel G. Kooreman
- , Julia D. Ransohoff
- & Joseph C. Wu
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Commentary |
A targeted approach to cancer imaging and therapy
Nanoparticle-based imaging plays a crucial role in cancer diagnosis and treatment. Here, we discuss the modalities used for molecular imaging of the tumour microenvironment and image-guided interventions including drug delivery, surgery and ablation therapy.
- Chun Li
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News & Views |
The only way is up
An efficient scheme that realizes broad tunability of photon upconversion in core–shell nanoparticles may lead to applications in biosensing, security labelling and more.
- Nicholas Kotov
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