Histone post-translational modifications

Histone post-translational modifications are covalent modifications of histones by phosphorylation on serine or threonine residues, methylation on lysine or arginine, acetylation and deacetylation of lysines, ubiquitylation of lysines and sumoylation of lysines. Histone modifications are proposed to affect chromosome structure and function, for instance during transcription and chromatin remodelling processes.

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Latest Research and Reviews

  • Research | | open

    Substitution of lysine 27 with methionine in histone H3.3 (H3.3K27M) is a driver mutation of pediatric high-grade gliomas. Here the authors show that H3.3K27M-mediated alterations in H3K27me3 distribution result in ectopic DNA replication and cell cycle progression of germ cells in Caenorhabditis elegans, through JNK pathway misregulation.

    • Kamila Delaney
    • , Maude Strobino
    • , Joanna M. Wenda
    • , Andrzej Pankowski
    •  & Florian A. Steiner
  • Research | | open

    Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.

    • Yi Zhang
    • , Younghoon Jang
    • , Ji-Eun Lee
    • , JaeWoo Ahn
    • , Longxia Xu
    • , Michael R. Holden
    • , Evan M. Cornett
    • , Krzysztof Krajewski
    • , Brianna J. Klein
    • , Shu-Ping Wang
    • , Yali Dou
    • , Robert G. Roeder
    • , Brian D. Strahl
    • , Scott B. Rothbart
    • , Xiaobing Shi
    • , Kai Ge
    •  & Tatiana G. Kutateladze
  • Research | | open

    Post-translational protein modifications can affect lifespan and aging but age-dependent ubiquitylation changes have not yet been systematically characterized. Here, the authors analyze age-related proteome and ubiquitylome dynamics in Drosophila and identify increasing H2A ubiquitylation as a conserved aging marker.

    • Lu Yang
    • , Zaijun Ma
    • , Han Wang
    • , Kongyan Niu
    • , Ye Cao
    • , Le Sun
    • , Yang Geng
    • , Bo Yang
    • , Feng Gao
    • , Zuolong Chen
    • , Zhen Wu
    • , Qingqing Li
    • , Yong Shen
    • , Xumin Zhang
    • , Hong Jiang
    • , Yelin Chen
    • , Rui Liu
    • , Nan Liu
    •  & Yaoyang Zhang
  • Research | | open

    Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.

    • Karla Rubio
    • , Indrabahadur Singh
    • , Stephanie Dobersch
    • , Pouya Sarvari
    • , Stefan Günther
    • , Julio Cordero
    • , Aditi Mehta
    • , Lukasz Wujak
    • , Hector Cabrera-Fuentes
    • , Cho-Ming Chao
    • , Peter Braubach
    • , Saverio Bellusci
    • , Werner Seeger
    • , Andreas Günther
    • , Klaus T. Preissner
    • , Malgorzata Wygrecka
    • , Rajkumar Savai
    • , Dulce Papy-Garcia
    • , Gergana Dobreva
    • , Mathias Heikenwalder
    • , Soni Savai-Pullamsetti
    • , Thomas Braun
    •  & Guillermo Barreto
  • Research | | open

    Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as previously proposed, but is bistable, meaning that the system switches frequently between stable active and silent states.

    • Kim Sneppen
    •  & Leonie Ringrose

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