We developed MAbID, a method for combined genomic profiling of histone modifications and chromatin-binding proteins in single cells, enabling researchers to study the interconnectivity between gene-regulatory mechanisms. We demonstrated MAbID’s implementation in profiling multifactorial changes in chromatin signatures during in vitro neural differentiation and in primary mouse bone marrow tissue.
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This is a summary of: Lochs, S. J. A. et al. Combinatorial single-cell profiling of major chromatin types with MAbID. Nat. Methods https://doi.org/10.1038/s41592-023-02090-9 (2023).
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Multifactorial epigenomic profiling of six chromatin states in single cells. Nat Methods 21, 20–21 (2024). https://doi.org/10.1038/s41592-023-02091-8
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DOI: https://doi.org/10.1038/s41592-023-02091-8
