Research Highlight |
Featured
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Research Highlight |
A single-cell multiomics profile of Fontan-associated liver disease
- Katrina Ray
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Review Article |
Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus
Receptive anal intercourse (RAI) is an important consideration in gastrointestinal disorders and cancers. This Review discusses the anorectum as a sexual organ, providing an overview of pleasurable and problematic RAI and how gastrointestinal disease itself and associated treatments (such as surgery) can affect RAI. Strategies to manage problematic RAI to improve sexual health are also described.
- Daniel R. Dickstein
- , Collin R. Edwards
- & Deborah C. Marshall
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Research Highlight |
Telemedicine for hepatitis C virus treatment in opioid treatment programmes
- Jordan Hindson
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Review Article |
Mitochondrial function and gastrointestinal diseases
Mitochondria of the intestinal epithelium are vital in intestinal health and disease. This Review provides a comprehensive overview of intestinal epithelial cell mitochondrial dysfunction in inflammatory bowel diseases and colorectal cancer and discusses mitochondrial-targeted therapeutics for these diseases.
- Parsa S. Haque
- , Neeraj Kapur
- & Arianne L. Theiss
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Review Article |
Pouchitis: pathophysiology and management
Pouchitis is a common condition that can occur after intestinal surgery. In this Review, Shen discusses our current understanding of the multifactorial pathophysiology, diagnosis and management of pouchitis, primarily in patients with underlying ulcerative colitis.
- Bo Shen
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Comment |
Promoting allyship to support and uplift the LGBTQIA+ community
The lesbian, gay, bisexual, transgender, queer, intersex and asexual (LGBTQIA+) community navigates a complex social landscape marked by strides in acceptance alongside enduring discrimination. Allies — individuals outside of the LGBTQIA+ spectrum who support and advocate for this community — are paramount, with allyship playing a critical part in influencing the health and well-being of LGBTQIA+ individuals.
- Daniel J. Huynh
- , Sonali Paul
- & Nikki Duong
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Perspective |
The changing metabolic landscape of bile acids – keys to metabolism and immune regulation
Bile acids have important roles in human metabolism and immune regulation. In this Perspective, Dorrestein and colleagues discuss the technologies and data science-related approaches that are improving our understanding of the diversity of bile acids and their multifaceted roles.
- Ipsita Mohanty
- , Celeste Allaband
- & Pieter C. Dorrestein
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Clinical Outlook |
New understanding of hepatobiliary MRI
Magnetic resonance imaging following injection of hepatobiliary contrast agents improves the detection of hepatocellular carcinomas when contrast agent accumulations in tumours and the surrounding pathological liver differ. However, tissue accumulation is poorly investigated, and this Clinical Outlook article highlights experimental data to understand better contrast agent accumulation in human pathological livers.
- Catherine M. Pastor
- & Valérie Vilgrain
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Research Highlight |
Biomarker shows no clinical use in guiding treatment for Crohn’s disease
- Eleni Kotsiliti
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In Brief |
Linaclotide for functional constipation in paediatric patients: phase III results
- Jordan Hindson
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In Brief |
Sintilimab as adjuvant therapy for patients with resected HCC at high risk of recurrence
- Jordan Hindson
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Review Article |
Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions
Coeliac disease is an autoinflammatory disease, with the only available treatment being a lifelong gluten-free diet. Alternative therapeutic approaches are needed. This Review explores the concept of tolerance-inducing therapies for coeliac disease, highlighting the underlying mechanisms, progress, challenges and future directions.
- Ludvig M. Sollid
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Research Highlight |
A role for the gut microbiota in immune checkpoint inhibitor-induced colitis
- Katrina Ray
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Research Highlight |
Effect of expectation of gluten intake on non-coeliac gluten sensitivity
- Jordan Hindson
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Clinical Outlook |
Are all the IL-23 blockers the same in inflammatory bowel disease?
A substantial percentage of patients with inflammatory bowel disease (IBD) exhibit biologic treatment failure or loss of response over time. This article explores the effectiveness and safety of monoclonal antibodies targeting the IL-23 pathway in treating IBD; continued research is needed to address lingering questions regarding long-term safety and efficacy.
- Silvio Danese
- & Laurent Peyrin-Biroulet
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Evidence-based Guidelines |
Guidelines for best practices in monitoring established coeliac disease in adult patients
Coeliac disease is a chronic inflammatory disease triggered by gluten consumption in individuals with a genetic susceptibility. These Evidence-Based Guidelines provide recommendations for improving the health care of the patients and discuss future perspectives.
- Luca Elli
- , Daniel Leffler
- & David S. Sanders
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Year in Review |
Upgrading therapeutic ambitions and treatment outcomes
Important studies published in 2023 outlined new agents and strategies for the management of inflammatory bowel disease. Therapeutic ambitions for the management of inflammatory bowel disease were raised by the success of combinations of biologic agents in ulcerative colitis and early surgical resection in Crohn’s disease.
- Paulo Gustavo Kotze
- & Severine Vermeire
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Year in Review |
Microbiota-based biomarkers and therapeutics for cancer management
New light is being shed on the interactions between the gut microbiome, cancer cell signalling and the host immune response. With this knowledge, microbiota-based approaches for improving cancer prevention, prognostication and therapy have started to materialize and will contribute to reducing the global cancer burden.
- William K. K. Wu
- & Jun Yu
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Review Article |
Deciphering the different phases of preclinical inflammatory bowel disease
Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID). Here, the authors review evidence on the preclinical phase of IBD, outlining and describing the proposed at-risk, initiation and expansion phases. Overlap with other IMIDs is discussed alongside the possible future directions for research into preclinical IBD.
- Jonas J. Rudbaek
- , Manasi Agrawal
- & Tine Jess
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Research Highlight |
A distinct CD103+Vγ4+ γδ T cell subset is linked to lesion healing and improved prognosis
- Caroline Barranco
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Perspective |
Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease
Cirrhosis recompensation is gradually gaining traction, but a definition for recompensation in nonalcoholic fatty liver disease (NAFLD)-related cirrhosis is currently lacking. This Perspective provides an overview of the natural history of NAFLD and discusses NAFLD-related cirrhosis recompensation.
- Gong Feng
- , Luca Valenti
- & Ming-Hua Zheng
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Research Highlight |
Understanding remodelling of bile ducts to promote polycystic liver disease
- Katrina Ray
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Expert Recommendation |
Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards
In this Expert Recommendation, Uhlig and colleagues review the therapeutic landscape for monogenic inflammatory bowel disease and propose recommendations for standardized reporting of clinical outcomes.
- Holm H. Uhlig
- , Claire Booth
- & Aleixo M. Muise
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Clinical Outlook |
The current status of imaging in liver fibrosis
Imaging techniques for assessing liver fibrosis are advancing. This Clinical Outlook article discusses the best practices and reviews emerging options for magnetic resonance and ultrasound-based elastography.
- Kathryn J. Fowler
- & Mustafa R. Bashir
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